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NCT07220122 · ClinicalTrials.gov registry record · Early Phase 1
Impact of Exogenous Ketones on Breathing in Healthy Volunteers
A Early Phase 1 study, sponsored by Johns Hopkins University.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 20
- Enrollment target
NCT07220122: Recruiting Early Phase 1 study, sponsored by Johns Hopkins University.
NCT07220122 is a Early Phase 1 study that is actively recruiting participants, run by Johns Hopkins University. The registered enrollment target is 20 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (62% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07220122, a Early Phase 1 study, is actively recruiting participants, sponsored by Johns Hopkins University.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 20 participants
- Enrollment target
Study Summary
Exogenous ketones (EK) are compounds that can increase the level of ketones in the body without needing to change what an individual eats. Although EK have been researched mainly in relation to energy and exercise, there haven't been many studies focusing specifically on how EKs affect breathing using well-established scientific methods. The investigators believe that EK may help improve breathing, which could be beneficial for situations like high altitudes, sleep apnea, and exercise. To explore how EK might influence breathing, the investigators are conducting a randomized, placebo-controlled crossover study with healthy volunteers.
Primary Outcome
Minute ventilation (L/min) while breathing 7% Carbon Dioxide (CO2). Measured once during each visit.
Interventions
- DIETARY_SUPPLEMENT Placebo
- DIETARY_SUPPLEMENT 1,3 butanediol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2026-03-12 |
| Est. Completion | 2027-02-10 |
| Phase | Early Phase 1 |
What NCT07220122 shows while recruiting
NCT07220122 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (62% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT07220122 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07220122 about?
NCT07220122 is a clinical study titled "Impact of Exogenous Ketones on Breathing in Healthy Volunteers". Exogenous ketones (EK) are compounds that can increase the level of ketones in the body without needing to change what an individual eats. Although EK have been researched mainly in relation to energy and exercise, there haven't been many studies focusing specifically on how EKs affect breathing us...
What is the current status of trial NCT07220122?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 20 participants. The study started on 2026-03-12. Estimated completion is 2027-02-10.
What interventions are being tested in trial NCT07220122?
The interventions under investigation include: Placebo (DIETARY_SUPPLEMENT), 1,3 butanediol (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT07220122?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07220122's enrollment target sits among peer trials
20 1157th of 2000 higher than 710 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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