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NCT07216209 · ClinicalTrials.gov registry record · NA
The Impact of Exercise on the Tumor Microenvironment in Patients With Lung Cancer
A NA study, sponsored by University of Arizona.
- Recruiting
- Registry status
- NA
- Development phase
- 48
- Enrollment target
NCT07216209: Recruiting NA study, sponsored by University of Arizona.
NCT07216209 is a NA study that is actively recruiting participants, run by University of Arizona. The registered enrollment target is 48 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07216209, a NA study, is actively recruiting participants, sponsored by University of Arizona.
- RECRUITING
- Registry status
- NA
- Development phase
- 48 participants
- Enrollment target
Study Summary
There is increased interest and knowledge about the lung cancer tumor microenvironment (TME). Investigators hypothesize that patients with better baseline physiologic health will have better post-operative outcomes and that strenuous exercise will alter the TME and genetic make-up of the tumor, improving the tumor immune response. Investigators aim to identify the peri-operative and clinical outcomes that differ based on pre-operative VO2max, HRV and resting heart rate following resection of early-stage lung cancer. The physiologic states that are individual and measurable with wearable devices include but are not limited to VO2max, heart rate variability (HRV), and average resting heart rate. Investgators hypothesize that a patient's pre-operative physiologic function with higher VO2max, HRV and lower resting heart rate will be associated with improved peri-operative and post-operative outcomes. Second, investigators will compare alterations in TME based on targeted pre-operative exercise (60-80% of their VO2 max for 75min/week x2 weeks) compared to normal activity adults following resection of early-stage lung cancer. Investigators hypothesize that strenuous exercise in the pre-operative period will impact the TME by increasing levels of cytokines.
Primary Outcome
Lung cancer specimens will be collected from all patients at the time of surgery. Investigators will perform real-time PCR to identify levels of PDL-1
Interventions
- BEHAVIORAL EXERCISE TRAINING WITH OR WITHOUT MEDICATION
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2026-01-13 |
| Est. Completion | 2030-01-15 |
| Phase | NA |
What NCT07216209 shows while recruiting
NCT07216209 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 1 intervention - of which EXERCISE TRAINING WITH OR WITHOUT MEDICATION is the first listed.
NCT07216209 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07216209 about?
NCT07216209 is a clinical study titled "The Impact of Exercise on the Tumor Microenvironment in Patients With Lung Cancer". There is increased interest and knowledge about the lung cancer tumor microenvironment (TME). Investigators hypothesize that patients with better baseline physiologic health will have better post-operative outcomes and that strenuous exercise will alter the TME and genetic make-up of the tumor, impr...
What is the current status of trial NCT07216209?
This trial is currently recruiting. It is a NA study. The enrollment target is 48 participants. The study started on 2026-01-13. Estimated completion is 2030-01-15.
What interventions are being tested in trial NCT07216209?
The interventions under investigation include: EXERCISE TRAINING WITH OR WITHOUT MEDICATION (BEHAVIORAL).
Who is sponsoring clinical trial NCT07216209?
This trial is sponsored by University of Arizona, which has 349 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07216209's enrollment target sits among peer trials
48 1381st of 2000 higher than 601 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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