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NCT07211412 · ClinicalTrials.gov registry record · NA
Acute Cryotherapy on Musculoskeletal Function and Biomarkers
A NA study, sponsored by University of Texas, El Paso.
- Not yet
- Registry status
- NA
- Development phase
- 60
- Enrollment target
NCT07211412: Clinical Trial NA study, sponsored by University of Texas, El Paso.
NCT07211412 is a NA study that has not yet begun recruiting, run by University of Texas, El Paso. The registered enrollment target is 60 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07211412, a NA study, has not yet begun recruiting, sponsored by University of Texas, El Paso.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
Study Summary
In 2020, Dubois and Esculier proposed a paradigm shift in the acute management of musculoskeletal injuries, advocating for the transition from the traditional PRICE protocol- Protect, Rest, Ice, Compression, Elevation-to the more holistic PEACE \& LOVE framework. This updated model emphasizes Protection, Elevation, Avoiding anti-inflammatories, Compression, and Education, followed by Load, Optimism, Vascularization, and Exercise. Notably, the PEACE \& LOVE approach omits the use of ice, a decision that has sparked considerable debate. While the rationale centers on avoiding interference with the natural inflammatory and regenerative processes, this omission stands in contrast to a substantial body of animal research suggesting that cryotherapy can mitigate secondary tissue injury by reducing inflammation and metabolic activity. Despite its widespread clinical use, human studies have yet to provide conclusive evidence supporting or refuting the efficacy of cryotherapy in acute injury management, leaving clinicians to navigate between tradition, emerging evidence, and evolving philosophies of care. Even though it is important to consider natural inflammation for a better regenerative process, animal models have shown that the original injury can elicit oxidative stress, which will enhance cellular damage (secondary damage) and inflammation. Clinically, it is unknown if this secondary damage would increase functional impairment. Therefore, this proposal will determine if cryotherapy can decrease secondary damage, after exercise-induced muscle damage, and if this decrease is associated to lower inflammation, oxidative stress and functional impairments.
Primary Outcome
Laid down on an isokinetic dynamometer system (Humac-Norm, Computer Sports Medicine, inc., Stoughton, MA), participants will be asked to flex their non-dominant arm (pull with their hand) against the dynamometer. They will perform 3 tries with 1 minute between tries and the peak value will be considered the MVIC.
Interventions
- OTHER Cryotherapy
- OTHER Eccentric exercise-induced muscle damage
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2025-10-15 |
| Est. Completion | 2026-05-15 |
| Phase | NA |
What is known before NCT07211412 opens enrollment
NCT07211412 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 2 interventions - of which Cryotherapy is the first listed.
NCT07211412 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07211412 about?
NCT07211412 is a clinical study titled "Acute Cryotherapy on Musculoskeletal Function and Biomarkers". In 2020, Dubois and Esculier proposed a paradigm shift in the acute management of musculoskeletal injuries, advocating for the transition from the traditional PRICE protocol- Protect, Rest, Ice, Compression, Elevation-to the more holistic PEACE \& LOVE framework. This updated model emphasizes Protec...
What is the current status of trial NCT07211412?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2025-10-15. Estimated completion is 2026-05-15.
What interventions are being tested in trial NCT07211412?
The interventions under investigation include: Cryotherapy (OTHER), Eccentric exercise-induced muscle damage (OTHER).
Who is sponsoring clinical trial NCT07211412?
This trial is sponsored by University of Texas, El Paso, which has 17 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07211412's enrollment target sits among peer trials
60 1164th of 2000 higher than 745 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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