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Gene Therapy for HER-Positive Cancer (SENTRY-HER2)
NCT07192432 · View on ClinicalTrials.gov ↗
Study Summary
This is a Phase 1/2, first-in-human, open-label, dose-escalating and expansion trial designed to assess the safety and efficacy of VNX-202 in patients with HER2 positive cancers.
Conditions Studied
Interventions
- GENETIC Dose Level 1, VNX-202
- GENETIC Dose Level 2, VNX-202
- GENETIC Dose Level 3, VNX-202
- GENETIC Dose Level 4, VNX-202
Study Locations (3)
California
- Valkyrie Clinical Trials — Los Angeles
Colorado
- SCRI Denver DDU at HealthOne — Denver
Tennessee
- SCRI Oncology Partners — Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 27 participants |
| Start Date | 2025-11-18 |
| Est. Completion | 2033-10 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07192432
The ClinicalTrials.gov registry entry for NCT07192432 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 27 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Vironexis Biotherapeutics, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with HER2 Expressing Solid Tumors appearing as the primary indexed condition, and to 4 interventions — of which Dose Level 1, VNX-202 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07192432 reports 3 study locations spanning 3 distinct geographic areas — top geographies include California, Colorado, Tennessee. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07192432 about?
NCT07192432 is a clinical study titled "Gene Therapy for HER-Positive Cancer (SENTRY-HER2)". This is a Phase 1/2, first-in-human, open-label, dose-escalating and expansion trial designed to assess the safety and efficacy of VNX-202 in patients with HER2 positive cancers.
What is the current status of trial NCT07192432?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 27 participants. The study started on 2025-11-18. Estimated completion is 2033-10.
What conditions does trial NCT07192432 study?
This clinical trial studies the following conditions: HER2 Expressing Solid Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07192432?
The interventions under investigation include: Dose Level 1, VNX-202 (GENETIC), Dose Level 2, VNX-202 (GENETIC), Dose Level 3, VNX-202 (GENETIC), Dose Level 4, VNX-202 (GENETIC). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07192432?
This trial is sponsored by Vironexis Biotherapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07192432 being conducted?
This trial has 3 study locations across California, Colorado, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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