Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07186660 · ClinicalTrials.gov registry record · Phase 2
Evaluation of a Novel Insulin Sensitizer in People With Type 1 Diabetes
A Phase 2 study of Type 1 Diabetes (T1D) and Cardiovascular Health, sponsored by University of Virginia.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT07186660: Recruiting Phase 2 study of Type 1 Diabetes (T1D) and Cardiovascular Health, sponsored by University of Virginia.
NCT07186660 is a Phase 2 study of Type 1 Diabetes (T1D) and Cardiovascular Health that is actively recruiting participants, run by University of Virginia. The registered enrollment target is 40 participants, below the 178-participant average among 17 other Type 1 Diabetes (T1D) trials with a reported enrollment target (78% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07186660, a Phase 2 study of Type 1 Diabetes (T1D) and Cardiovascular Health, is actively recruiting participants, sponsored by University of Virginia.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to see if the study drug CIR-0602K will improve glucose time-in-range and/or lower total daily insulin dose in people with type 1 diabetes who are using closed-loop automated insulin delivery. Researchers will compare CIR-0602K to a placebo (a look-alike substance that contains no drug) to see if it achieves the investigational endpoints. If the study results show that the drug works to increase time-in-range and lower insulin doses, this will lead to further studies which may then make the drug available to the public.
Primary Outcome
Glucose time 70-180 mg/dL
Conditions Studied
Interventions
- DRUG Placebo
- DRUG CIR-0602K
Study Locations (1)
Virginia
- University of Virginia - Charlottesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2026-02-22 |
| Est. Completion | 2028-09 |
| Phase | Phase 2 |
What NCT07186660 shows while recruiting
NCT07186660 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 178-participant average among 17 other Type 1 Diabetes (T1D) trials with a reported enrollment target (78% lower).
The record links to 5 conditions, with Type 1 Diabetes (T1D) appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT07186660 reports a single indexed study location in Virginia.
Frequently Asked Questions
What is clinical trial NCT07186660 about?
NCT07186660 is a clinical study titled "Evaluation of a Novel Insulin Sensitizer in People With Type 1 Diabetes". The purpose of this study is to see if the study drug CIR-0602K will improve glucose time-in-range and/or lower total daily insulin dose in people with type 1 diabetes who are using closed-loop automated insulin delivery. Researchers will compare CIR-0602K to a placebo (a look-alike substance that c...
What is the current status of trial NCT07186660?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 40 participants. The study started on 2026-02-22. Estimated completion is 2028-09.
What conditions does trial NCT07186660 study?
This clinical trial studies the following conditions: Type 1 Diabetes (T1D), Cardiovascular Health, Insulin, Glycemic Control for Diabetes Mellitus, Ketones.
What interventions are being tested in trial NCT07186660?
The interventions under investigation include: Placebo (DRUG), CIR-0602K (DRUG).
Who is sponsoring clinical trial NCT07186660?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07186660 being conducted?
This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Type 1 Diabetes (T1D)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07186660's enrollment target sits among peer trials
40 12th of 17 higher than 5 of 17 other Type 1 Diabetes (T1D) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Type 1 Diabetes (T1D) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Lactobacillus Johnsonii Supplementation in Adults With T1D
ACTIVE NOT RECRUITING · Phase 2
-
Lactobacillus Johnsonii in Children and Adolescents With T1D
COMPLETED · Phase 2
-
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
RECRUITING · Phase 1
-
Monocytes in Subjects With Type 1 Diabetes and Chronic Kidney Disease
RECRUITING
-
Building and Sustaining Exercise Habits for Adults With Type 1 Diabetes
RECRUITING · NA
-
Circadian Mechanisms, Glucose, and CV Risks in T1D
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01306019 · 40 participants · Phase 1
Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)
- NCT01608152 · 40 participants
Development of a Video Game for the Improvement of Outcomes in Stem Cell Transplant Survivors
- NCT01668082 · 40 participants · NA
An Investigation of Brain Tumor Metabolism in Patients Undergoing Surgical Resection
- NCT02015013 · 40 participants · Phase 2
Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI