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NCT07177300 · ClinicalTrials.gov registry record · Phase 4
Effectiveness of Nontraditional Hydroxyurea Algorithms: Novel and Clinical Evaluations (ENHANCE)
A Phase 4 study of Sickle Cell Anemia (HbSS) and Sickle-β0-thalassemia (HbSβ0), sponsored by Children's Hospital Medical Center, Cincinnati.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT07177300 is a Phase 4 study of Sickle Cell Anemia (HbSS) and Sickle-β0-thalassemia (HbSβ0) that is actively recruiting participants, run by Children's Hospital Medical Center, Cincinnati. The registered enrollment target is 50 participants. The trial reports 1 study location across 1 state.
The verdict
NCT07177300, a Phase 4 study of Sickle Cell Anemia (HbSS) and Sickle-β0-thalassemia (HbSβ0), is actively recruiting participants, sponsored by Children's Hospital Medical Center, Cincinnati.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
The main reason for this research study is to learn more about hydroxyurea and the treatment of sickle cell anemia (SCA). Hydroxyurea is a medication that has been studied for many years and has been shown to provide benefits for people with SCA. In this research study, the investigators hope to learn more about how to improve the dosing and monitoring of hydroxyurea and learn more about the long-term effects of hydroxyurea over time. Hydroxyurea is usually dosed based only on your weight. Our study will use a new way to select a starting dose that is based on how each patient absorbs hydroxyurea.
Conditions Studied
Interventions
- DRUG PK-optimized oral hydroxyurea at MTD until 15 years of age.
Study Locations (1)
Ohio
- Cincinnati Children's Hospital Medical Center - Cincinnati
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2024-12-19 |
| Est. Completion | 2028-12 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07177300
The ClinicalTrials.gov registry entry for NCT07177300 describes a study currently listed as recruiting, categorized as Phase 4. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Children's Hospital Medical Center, Cincinnati, which has 571 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Sickle Cell Anemia (HbSS) appearing as the primary indexed condition, and to 1 intervention - of which PK-optimized oral hydroxyurea at MTD until 15 years of age. is the first listed.
NCT07177300 reports 1 study location spanning 1 distinct geographic area - top geographies include Ohio.
Frequently Asked Questions
What is clinical trial NCT07177300 about?
NCT07177300 is a clinical study titled "Effectiveness of Nontraditional Hydroxyurea Algorithms: Novel and Clinical Evaluations (ENHANCE)". The main reason for this research study is to learn more about hydroxyurea and the treatment of sickle cell anemia (SCA). Hydroxyurea is a medication that has been studied for many years and has been shown to provide benefits for people with SCA. In this research study, the investigators hope to le...
What is the current status of trial NCT07177300?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 50 participants. The study started on 2024-12-19. Estimated completion is 2028-12.
What conditions does trial NCT07177300 study?
This clinical trial studies the following conditions: Sickle Cell Anemia (HbSS), Sickle-β0-thalassemia (HbSβ0).
What interventions are being tested in trial NCT07177300?
The interventions under investigation include: PK-optimized oral hydroxyurea at MTD until 15 years of age. (DRUG).
Who is sponsoring clinical trial NCT07177300?
This trial is sponsored by Children's Hospital Medical Center, Cincinnati, which has 571 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07177300 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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