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NCT07151417 · ClinicalTrials.gov registry record · Phase 2
Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.
A Phase 2 study, sponsored by Walter Reed National Military Medical Center.
- Not yet
- Registry status
- Phase 2
- Development phase
- 240
- Enrollment target
NCT07151417 is a Phase 2 study that has not yet begun recruiting, run by Walter Reed National Military Medical Center. The registered enrollment target is 240 participants.
The verdict
NCT07151417, a Phase 2 study, has not yet begun recruiting, sponsored by Walter Reed National Military Medical Center.
- NOT YET RECRUITING
- Registry status
- Phase 2
- Development phase
- 240 participants
- Enrollment target
Study Summary
The goal of this clinical trial is to find out which type of steroid medicine, when added to a standard pain-control injection during total knee replacement surgery, works best at reducing pain, limiting opioid use, and improving recovery in adults undergoing surgery for severe knee arthritis or injury. The main questions it aims to answer are: Does adding a steroid to the injection improve pain control and reduce opioid use after surgery? Is the newer extended-release steroid (Zilretta) more effective and safer-especially for patients with diabetes-than the traditional steroid (methylprednisolone)? Researchers will compare: Standard pain-control injection alone Standard injection plus methylprednisolone Standard injection plus Zilretta to see which option provides better pain relief, less opioid use, and improved knee function. (Patients with diabetes or prediabetes will only be in the standard injection or Zilretta groups so researchers can study whether Zilretta is safer for blood sugar control.) Participants will: Be randomly assigned to one of the study groups during their total knee replacement surgery Receive the assigned pain-control injection around the knee joint Be followed after surgery to measure: Pain levels Opioid pain medication use Knee movement (range of motion) Whether another procedure (such as manipulation under anesthesia) is needed if the knee becomes too stiff Patient-reported outcome surveys about pain and function
Interventions
- DRUG PAI
- DRUG PAI + steroid
- DRUG PAI + zilretta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2025-09-01 |
| Est. Completion | 2026-08-31 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07151417
The ClinicalTrials.gov registry entry for NCT07151417 describes a study currently listed as not yet recruiting, categorized as Phase 2. The registered enrollment target is 240 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Walter Reed National Military Medical Center, which has 48 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which PAI is the first listed.
NCT07151417 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07151417 about?
NCT07151417 is a clinical study titled "Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.". The goal of this clinical trial is to find out which type of steroid medicine, when added to a standard pain-control injection during total knee replacement surgery, works best at reducing pain, limiting opioid use, and improving recovery in adults undergoing surgery for severe knee arthritis or inj...
What is the current status of trial NCT07151417?
This trial is currently not yet recruiting. It is a Phase 2 study. The enrollment target is 240 participants. The study started on 2025-09-01. Estimated completion is 2026-08-31.
What interventions are being tested in trial NCT07151417?
The interventions under investigation include: PAI (DRUG), PAI + steroid (DRUG), PAI + zilretta (DRUG).
Who is sponsoring clinical trial NCT07151417?
This trial is sponsored by Walter Reed National Military Medical Center, which has 48 total clinical trials registered on ClinicalTrials.gov.
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