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NCT07140874 · ClinicalTrials.gov registry record · Phase 2
Zinc as an Adjunctive Therapy for Cervical Dystonia
A Phase 2 study of Cervical Dystonia, sponsored by University of Florida.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT07140874: Recruiting Phase 2 study of Cervical Dystonia, sponsored by University of Florida.
NCT07140874 is a Phase 2 study of Cervical Dystonia that is actively recruiting participants, run by University of Florida. The registered enrollment target is 20 participants, below the 86-participant average among 15 other Cervical Dystonia trials with a reported enrollment target (77% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07140874, a Phase 2 study of Cervical Dystonia, is actively recruiting participants, sponsored by University of Florida.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to evaluate if supplemental zinc can prolong the duration of benefit of botulinum toxin injections in cervical dystonia patients receiving care at the University of Florida. The main aims are: 1. To evaluate the efficacy of zinc citrate supplementation in prolonging the duration of symptom relief provided by botulinum toxin type A (Botox) injections in cervical dystonia patients. 2. To assess the safety and tolerability of zinc supplementation in this patient population. 3. To analyze the potential influence of zinc supplementation on the quality of life and functional outcomes in cervical dystonia patients receiving Botox. Researchers will compare zinc citrate to a placebo (a look-alike substance that contains no active drug) to see if zinc works to extend the effects of Botox. Participants will: Take zinc citrate or a placebo every day for 3 months, then cross over to the alternative treatment for another 3 months. Visit the clinic every 3 months for Botox injections, check ups and surveys.
Primary Outcome
Time to return to baseline symptom severity using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) Severity Subscale. The TWSTRS Severity Subscale is scored from 0 to 35, with higher numbers indicating a more severe condition.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Zinc citrate
Study Locations (1)
Florida
- Norman Fixel Institute for Neurological Diseases - Gainesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2026-02-20 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 2 |
What NCT07140874 shows while recruiting
NCT07140874 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 86-participant average among 15 other Cervical Dystonia trials with a reported enrollment target (77% lower).
The record links to 1 condition, with Cervical Dystonia appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT07140874 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT07140874 about?
NCT07140874 is a clinical study titled "Zinc as an Adjunctive Therapy for Cervical Dystonia". The goal of this clinical trial is to evaluate if supplemental zinc can prolong the duration of benefit of botulinum toxin injections in cervical dystonia patients receiving care at the University of Florida. The main aims are: 1. To evaluate the efficacy of zinc citrate supplementation in prolong...
What is the current status of trial NCT07140874?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2026-02-20. Estimated completion is 2026-12-31.
What conditions does trial NCT07140874 study?
This clinical trial studies the following conditions: Cervical Dystonia.
What interventions are being tested in trial NCT07140874?
The interventions under investigation include: Placebo (DRUG), Zinc citrate (DRUG).
Who is sponsoring clinical trial NCT07140874?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07140874 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cervical Dystonia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07140874's enrollment target sits among peer trials
20 13th of 15 the lowest of 15 other Cervical Dystonia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cervical Dystonia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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