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NCT02131467 · ClinicalTrials.gov registry record · Phase 1
Safety and Tolerability of Perampanel in Cervical Dystonia
A Phase 1 study of Cervical Dystonia, sponsored by University Health Network, Toronto.
- Completed
- Registry status
- Phase 1
- Development phase
- 25
- Enrollment target
- 5
- Study locations
NCT02131467: Completed Phase 1 study of Cervical Dystonia, sponsored by University Health Network, Toronto.
NCT02131467 is a Phase 1 study of Cervical Dystonia that has completed, run by University Health Network, Toronto. The registered enrollment target is 25 participants, below the 85-participant average among 15 other Cervical Dystonia trials with a reported enrollment target (71% lower). The trial reports 5 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02131467, a Phase 1 study of Cervical Dystonia, has completed, sponsored by University Health Network, Toronto.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 25 participants
- Enrollment target
- 5
- Study locations
Study Summary
Cervical dystonia (CD) is the most common focal dystonia. Currently there are no effective oral medications for the treatment of CD. While botulinum toxin injections improve symptoms, they require repeated injections by a trained physician and some patients stop responding to injections or never respond at all. Therefore, alternative treatment options for CD are needed. One new agent is a drug that targets glutamate receptors that are thought to be involved dystonia. This drug, perampanel, was originally developed for epilepsy and is licensed for use in the USA and Canada for treating epilepsy. The purpose of this study is to test the effectiveness of perampanel in treating the symptoms of CD.
Primary Outcome
Tolerability will be assessed by counting number of subjects able to remain on drug
Conditions Studied
Interventions
- DRUG Perampanel
Study Locations (5)
Georgia
- Emory University School of Medicine - Atlanta
Illinois
- Rush University Medical Center - Chicago
New York
- Beth Israel Medical Center - New York
Ohio
- Cleveland Clinic - Cleveland
Ontario
- Toronto Western Hospital - Toronto
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2017-09-01 |
| Est. Completion | 2020-02-28 |
| Phase | Phase 1 |
What the finished NCT02131467 record still lists
NCT02131467 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 25 participants, a relatively small participant target, below the 85-participant average among 15 other Cervical Dystonia trials with a reported enrollment target (71% lower).
The record links to 1 condition, with Cervical Dystonia appearing as the primary indexed condition, and to 1 intervention - of which Perampanel is the first listed.
NCT02131467 lists 5 locations in 5 states (Georgia, Illinois, New York).
Frequently Asked Questions
What is clinical trial NCT02131467 about?
NCT02131467 is a clinical study titled "Safety and Tolerability of Perampanel in Cervical Dystonia". Cervical dystonia (CD) is the most common focal dystonia. Currently there are no effective oral medications for the treatment of CD. While botulinum toxin injections improve symptoms, they require repeated injections by a trained physician and some patients stop responding to injections or never res...
What is the current status of trial NCT02131467?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 25 participants. The study started on 2017-09-01. Estimated completion is 2020-02-28.
What conditions does trial NCT02131467 study?
This clinical trial studies the following conditions: Cervical Dystonia.
What interventions are being tested in trial NCT02131467?
The interventions under investigation include: Perampanel (DRUG).
Who is sponsoring clinical trial NCT02131467?
This trial is sponsored by University Health Network, Toronto, which has 23 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02131467 being conducted?
This trial has 5 study locations across Georgia, Illinois, New York, Ohio, Ontario. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cervical Dystonia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02131467's enrollment target sits among peer trials
25 12th of 15 higher than 4 of 15 other Cervical Dystonia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cervical Dystonia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Deep Brain Stimulation to Treat Cervical Dystonia
COMPLETED · Phase 1
-
Botulinum Toxin Type A (Botox) for the Treatment of Cervical Dystonia and Upper Thoracic Muscular Pain
COMPLETED · Phase 1
-
A Study of IPN10200 for the Treatment of Cervical Dystonia in Adults
RECRUITING · Phase 2
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Safety and Effectiveness of Valbenazine as Adjunct Therapy to Botulinum Toxin Injections in Cervical Dystonia
RECRUITING · Phase 2
-
Effect of Vibro-tactile Stimulation Intensity on Head Posture in Cervical Dystonia
RECRUITING · NA
-
Zinc as an Adjunctive Therapy for Cervical Dystonia
RECRUITING · Phase 2
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