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RECRUITING Phase 2

A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)

NCT07133633 · View on ClinicalTrials.gov ↗

Study Summary

Researchers are looking for new ways to treat radiographic axial spondyloarthritis (r-axSpA). R-axSpA is a type of arthritis that causes pain, stiffness, and inflammation (swelling) in the spine and joints in the pelvis (hip bone). Radiographic means the damage it causes can be seen on X-rays. This study will help find out if a study medicine called tulisokibart can treat symptoms of r-axSpA. Researchers will look at different doses of tulisokibart. Researchers want to know if at least one of the study doses of tulisokibart works better than a placebo to improve r-axSpA symptoms. A placebo looks like the study medicine but has no study medicine in it. Using a placebo helps researchers better understand the effects of the study medicine.

Interventions

  • DRUG Placebo
  • DRUG Tulisokibart

Study Locations (20)

Arizona

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Chandler ( Site 0036) — Chandler
  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Flagstaff ( Site 0021) — Flagstaff
  • Arizona Arthritis & Rheumatology Associates, P.C. - Gilbert ( Site 0022) — Gilbert
  • AARA Arizona Arthritis & Rheumatology Associates, P.C. - Glendale ( Site 0056) — Glendale
  • Arizona Arthritis & Rheumatology Associates, P.C. - Tucson ( Site 0025) — Tucson

California

  • TriWest Research Associates - Chula Vista ( Site 0013) — Chula Vista
  • Newport Huntington Medical Group ( Site 0005) — Huntington Beach
  • Cohen Medical Centers ( Site 0034) — Thousand Oaks
  • Inland Rheumatology Clinical Trials, Inc. ( Site 0002) — Upland

Florida

  • Arthritis and Rheumatic Disease Specialties ( Site 0016) — Aventura
  • Bay Area Arthritis and Osteoporosis ( Site 0041) — Brandon
  • GNP Research - Hollywood ( Site 0020) — Cooper City
  • Innovation Medical Research Center ( Site 0012) — Palmetto Bay

Illinois

  • Chicago Arthritis & Regenerative Medicine ( Site 0042) — Chicago
  • Willow Rheumatology and Wellness, PLLC ( Site 0035) — Willowbrook

Missouri

  • Kansas City Physician Partners ( Site 0027) — Kansas City
  • Velocity Clinical Research - West County Rheumatology, St. Louis ( Site 0038) — St Louis

Maryland

  • Arthritis and Rheumatism Associates - Rockville ( Site 0019) — Rockville

Nebraska

  • Physician Research Collaboration, LLC ( Site 0057) — Lincoln

New Mexico

  • Inspire Santa Fe Medical Group ( Site 0011) — Santa Fe

Trial Details

FieldValue
Enrollment Target 315 participants
Start Date 2025-09-26
Est. Completion 2030-02-05
Phase Phase 2

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07133633

The ClinicalTrials.gov registry entry for NCT07133633 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 315 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Radiographic Axial Spondyloarthritis appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07133633 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Arizona, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07133633 about?

NCT07133633 is a clinical study titled "A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)". Researchers are looking for new ways to treat radiographic axial spondyloarthritis (r-axSpA). R-axSpA is a type of arthritis that causes pain, stiffness, and inflammation (swelling) in the spine and joints in the pelvis (hip bone). Radiographic means the damage it causes can be seen on X-rays. This...

What is the current status of trial NCT07133633?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 315 participants. The study started on 2025-09-26. Estimated completion is 2030-02-05.

What conditions does trial NCT07133633 study?

This clinical trial studies the following conditions: Radiographic Axial Spondyloarthritis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07133633?

The interventions under investigation include: Placebo (DRUG), Tulisokibart (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07133633?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07133633 being conducted?

This trial has 20 study locations across Arizona, California, Florida, Illinois, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial