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NCT07084896 · ClinicalTrials.gov registry record · Phase 1
Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Nirogacestat in Participants With RRMM
A Phase 1 study of Multiple Myeloma, sponsored by GlaxoSmithKline.
- Active
- Registry status
- Phase 1
- Development phase
- 106
- Enrollment target
- 20
- Study locations
NCT07084896: Active Phase 1 study of Multiple Myeloma, sponsored by GlaxoSmithKline.
NCT07084896 is a Phase 1 study of Multiple Myeloma that is active but no longer recruiting, run by GlaxoSmithKline. The registered enrollment target is 106 participants, below the 547-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (81% lower). The trial reports 20 study locations across 8 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07084896, a Phase 1 study of Multiple Myeloma, is active but no longer recruiting, sponsored by GlaxoSmithKline.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 106 participants
- Enrollment target
- 20
- Study locations
Study Summary
The primary purpose is to determine the safety and tolerability of belantamab mafodotin in combination with nirogacestat and to establish the recommended Phase 2 dose for combination treatment to explore in the cohort expansion (CE) phase in participants with RRMM. This study is a sub study of the Master protocol (NCT04126200).
Primary Outcome
Criteria for dose-limiting toxicity (DLT) included hematologic indicators such as Grade 3-5 febrile neutropenia and thrombocytopenia with bleeding. Non-hematologic criteria, excluding corneal toxicity, comprise Grade 3-5 toxicities, with exceptions for manageable nausea, vomiting, or diarrhea, controlled Grade 3 hypertension, and events linked to disease progression. Tumor lysis syndrome (TLS) of Grade 3 or 4, successfully managed within 7 days without end-organ damage, was considered. Corneal t
Conditions Studied
Interventions
- DRUG Belantamab mafodotin
- DRUG Nirogacestat
Study Locations (20)
Other
- GSK Investigational Site - Lille
- GSK Investigational Site - Villejuif
- GSK Investigational Site - Frankfurt
- GSK Investigational Site - Kiel
- GSK Investigational Site - Leipzig
- GSK Investigational Site - Athens
- GSK Investigational Site - Utrecht
- GSK Investigational Site - Oslo
- GSK Investigational Site - Katowice
- GSK Investigational Site - Lodz
- GSK Investigational Site - Lublin
- GSK Investigational Site - Moscow
- GSK Investigational Site - Incheon
Georgia
- 238995 - Atlanta
Massachusetts
- 240593 - Boston
Michigan
- 251164 - Grand Rapids
Wisconsin
- 239015 - Madison
Victoria
- GSK Investigational Site - Fitzroy
British Columbia
- GSK Investigational Site - Vancouver
Nova Scotia
- GSK Investigational Site - Halifax
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 106 participants |
| Start Date | 2020-06-08 |
| Est. Completion | 2027-03-11 |
| Phase | Phase 1 |
What the registry record for NCT07084896 still lists
NCT07084896 is an interventional study that assigns participants to a tested intervention. The registered 106 participants enrollment target is mid-sized for trials with a published cap, below the 547-participant average among 438 other Multiple Myeloma trials with a reported enrollment target (81% lower).
The record links to 1 condition, with Multiple Myeloma appearing as the primary indexed condition, and to 2 interventions - of which Belantamab mafodotin is the first listed.
NCT07084896 names 20 study sites across 8 states, led by Other, Georgia, Massachusetts.
Frequently Asked Questions
What is clinical trial NCT07084896 about?
NCT07084896 is a clinical study titled "Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Nirogacestat in Participants With RRMM". The primary purpose is to determine the safety and tolerability of belantamab mafodotin in combination with nirogacestat and to establish the recommended Phase 2 dose for combination treatment to explore in the cohort expansion (CE) phase in participants with RRMM. This study is a sub study of the M...
What is the current status of trial NCT07084896?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 106 participants. The study started on 2020-06-08. Estimated completion is 2027-03-11.
What conditions does trial NCT07084896 study?
This clinical trial studies the following conditions: Multiple Myeloma.
What interventions are being tested in trial NCT07084896?
The interventions under investigation include: Belantamab mafodotin (DRUG), Nirogacestat (DRUG).
Who is sponsoring clinical trial NCT07084896?
This trial is sponsored by GlaxoSmithKline, which has 1,345 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07084896 being conducted?
This trial has 20 study locations across Georgia, Massachusetts, Michigan, Wisconsin, Victoria. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Multiple Myeloma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07084896's enrollment target sits among peer trials
106 160th of 438 higher than 278 of 438 other Multiple Myeloma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Multiple Myeloma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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