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A Study to Compare the Combination of BMS-986504 With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion
NCT07063745 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to compare the clinical benefit of the combination of BMS-986504 (a selective MTA-cooperative inhibitor of PRMT5) plus pembrolizumab and chemotherapy versus placebo plus pembrolizumab and chemotherapy in first-line metastatic non-small cell lung cancer participants with homozygous MTAP deletion
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG Carboplatin
- DRUG Cisplatin
- OTHER Placebo
- DRUG BMS-986504
Study Locations (20)
Florida
- Local Institution - 0152 — Fort Lauderdale
- Mayo Clinic in Florida — Jacksonville
- Local Institution - 0430 — St. Petersburg
Michigan
- Local Institution - 0418 — Ann Arbor
- Local Institution - 0405 — Detroit
- Local Institution - 0420 — Traverse City
Arizona
- Mayo Clinic in Arizona - Phoenix — Phoenix
- Local Institution - 0120 — Tucson
California
- USC/Norris Comprehensive Cancer Center — Los Angeles
- Local Institution - 0444 — Los Angeles
Kentucky
- Baptist Health Lexington — Lexington
- University of Kentucky Chandler Medical Center — Lexington
Alaska
- Alaska Oncology and Hematology — Anchorage
Arkansas
- Highlands Oncology Group — Springdale
Idaho
- St. Luke's Cancer Institute: Boise — Boise
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 590 participants |
| Start Date | 2026-01-02 |
| Est. Completion | 2031-08-12 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07063745
The ClinicalTrials.gov registry entry for NCT07063745 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 590 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Bristol-Myers Squibb, which has 504 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Metastatic Non-small Cell Lung Cancer With MTAP Deletion appearing as the primary indexed condition, and to 5 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07063745 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Florida, Michigan, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07063745 about?
NCT07063745 is a clinical study titled "A Study to Compare the Combination of BMS-986504 With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion". The purpose of this study is to compare the clinical benefit of the combination of BMS-986504 (a selective MTA-cooperative inhibitor of PRMT5) plus pembrolizumab and chemotherapy versus placebo plus pembrolizumab and chemotherapy in first-line metastatic non-small cell lung cancer participants with ...
What is the current status of trial NCT07063745?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 590 participants. The study started on 2026-01-02. Estimated completion is 2031-08-12.
What conditions does trial NCT07063745 study?
This clinical trial studies the following conditions: Metastatic Non-small Cell Lung Cancer With MTAP Deletion. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07063745?
The interventions under investigation include: Pembrolizumab (DRUG), Carboplatin (DRUG), Cisplatin (DRUG), Placebo (OTHER), BMS-986504 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07063745?
This trial is sponsored by Bristol-Myers Squibb, which has 504 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07063745 being conducted?
This trial has 20 study locations across Alaska, Arizona, Arkansas, California, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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