Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis
NCT07003425 · View on ClinicalTrials.gov ↗
Study Summary
This is a multicenter, double-blind, Long-Term Extension (LTE) study to evaluate the long-term safety and efficacy of APG777 in patients with moderate-to-severe AD who have completed treatment in an APG777 Parent Study (NCT06395948). The LTE study will consist of 3 periods: 1) Screening Visit will coincide with the last visit of the Maintenance Period in the Parent Study 2) Extended Treatment Period 3) Post-treatment Follow-up Period. This study will be conducted in participants with atopic dermatitis (AD) who completed the Treatment Period in a prior APG777 study and who, in the opinion of the Investigator, would benefit from long-term treatment with APG777.
Conditions Studied
Interventions
- DRUG APG777
Study Locations (20)
Florida
- Investigational Site — Coral Gables
- Investigational Site — Jacksonville
- Investigational Site — Margate
Texas
- Investigational Site — Dallas
- Investigational Site — Frisco
- Investigational Site — San Antonio
California
- Investigational Site — Fountain Valley
- Investigational Site — Los Angeles
Michigan
- Investigational Site — Detroit
- Investigational Site — Troy
Ohio
- Investigational Site — Boardman
- Investigational Site — Mason
Georgia
- Investigational Site — Douglasville
Illinois
- Investigational Site — Skokie
Kentucky
- Investigational Site — Bowling Green
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 350 participants |
| Start Date | 2025-05-14 |
| Est. Completion | 2029-12 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07003425
The ClinicalTrials.gov registry entry for NCT07003425 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 350 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Apogee Therapeutics, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Atopic Dermatitis appearing as the primary indexed condition, and to 1 intervention — of which APG777 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07003425 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Florida, Texas, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07003425 about?
NCT07003425 is a clinical study titled "A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis". This is a multicenter, double-blind, Long-Term Extension (LTE) study to evaluate the long-term safety and efficacy of APG777 in patients with moderate-to-severe AD who have completed treatment in an APG777 Parent Study (NCT06395948). The LTE study will consist of 3 periods: 1) Screening Visit will ...
What is the current status of trial NCT07003425?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 350 participants. The study started on 2025-05-14. Estimated completion is 2029-12.
What conditions does trial NCT07003425 study?
This clinical trial studies the following conditions: Atopic Dermatitis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07003425?
The interventions under investigation include: APG777 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07003425?
This trial is sponsored by Apogee Therapeutics, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07003425 being conducted?
This trial has 20 study locations across California, Florida, Georgia, Illinois, Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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