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Double-blind, Randomized Trial of PRAX-628 in Adults With Focal Seizures to Evaluate Efficacy and Safety (POWER1)
NCT06999902 · View on ClinicalTrials.gov ↗
Study Summary
A Double-Blind, Randomized, Multicenter, Trial Evaluating the Efficacy and Safety of PRAX-628 in Adults With Focal Seizures (POWER1)
Conditions Studied
Interventions
- DRUG Placebo
- DRUG 20mg/day PRAX-628 for 6 weeks then 30mg/day PRAX-628 for remaining 6 weeks
Study Locations (20)
Texas
- Praxis Research Site — El Paso
- Praxis Research Site — Frisco
- Praxis Research Site — Round Rock
- Praxis Research Site — Seabrook
Other
- Praxis Research Site — Barcelona
- Praxis Research Site — Barcelona
- Praxis Research Site — Barcelona
- Praxis Research Site — Granda
Florida
- Praxis Research Site — DeLand
- Praxis Research Site — Miami Lakes
Missouri
- Praxis Research Site — Chesterfield
- Praxis Research Site — Ozark
Arizona
- Praxis Research Site — Phoenix
Illinois
- Praxis Research Site — Chicago
Louisiana
- Praxis Research Site — Lafayette
Maryland
- Praxis Research Site — Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 230 participants |
| Start Date | 2024-12-11 |
| Est. Completion | 2025-12-08 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06999902
The ClinicalTrials.gov registry entry for NCT06999902 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 230 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Praxis Precision Medicines, which has 6 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Focal Seizure appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06999902 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Texas, Other, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06999902 about?
NCT06999902 is a clinical study titled "Double-blind, Randomized Trial of PRAX-628 in Adults With Focal Seizures to Evaluate Efficacy and Safety (POWER1)". A Double-Blind, Randomized, Multicenter, Trial Evaluating the Efficacy and Safety of PRAX-628 in Adults With Focal Seizures (POWER1)
What is the current status of trial NCT06999902?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 230 participants. The study started on 2024-12-11. Estimated completion is 2025-12-08.
What conditions does trial NCT06999902 study?
This clinical trial studies the following conditions: Focal Seizure. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06999902?
The interventions under investigation include: Placebo (DRUG), 20mg/day PRAX-628 for 6 weeks then 30mg/day PRAX-628 for remaining 6 weeks (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06999902?
This trial is sponsored by Praxis Precision Medicines, which has 6 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06999902 being conducted?
This trial has 20 study locations across Arizona, Florida, Illinois, Louisiana, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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