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NCT06979492 · ClinicalTrials.gov registry record · Phase 4
Prophylactic Transfusion In Pregnant in Women With Sickle Cell Disease
A Phase 4 study of Sickle Cell Disease and Pregnancy Related, sponsored by Emory University.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT06979492: Recruiting Phase 4 study of Sickle Cell Disease and Pregnancy Related, sponsored by Emory University.
NCT06979492 is a Phase 4 study of Sickle Cell Disease and Pregnancy Related that is actively recruiting participants, run by Emory University. The registered enrollment target is 50 participants, below the 293-participant average among 213 other Sickle Cell Disease trials with a reported enrollment target (83% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06979492, a Phase 4 study of Sickle Cell Disease and Pregnancy Related, is actively recruiting participants, sponsored by Emory University.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this study is to determine if there is a positive effect of prophylactic red blood cell (RBC) transfusion of leukoreduced, ABO, Rh (D/Cc/Ee) and Kell matched blood compared to standard of care on the number of episodes of acute sickle cell disease (SCD) manifestations or pregnancy-related complications requiring acute health care encounters (acute care/ER/Hospital visits) or resulting in death over the entirety of pregnancy until 2 months post-partum in women with SCD. RBC transfusion is the only disease-modifying therapy for pregnant women with SCD, and it is considered a standard treatment option however, there exists no consensus on the role of transfusion therapy in preventing SCD-related pregnancy complications. Participants will be randomly assigned to repeated red blood cell transfusions or the standard of care. Participants will be on study for about 8-10 months (Pregnancy through 2 months post-partum).
Primary Outcome
Number of participants who require hospital admission during study participation divided by the total number of participants. Collected from medical records
Conditions Studied
Interventions
- BIOLOGICAL Prophylactic Transfusion Intervention group: Transfusion
- OTHER Control group
Study Locations (1)
Georgia
- Grady Health System - Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2026-04 |
| Est. Completion | 2028-05 |
| Phase | Phase 4 |
What NCT06979492 shows while recruiting
NCT06979492 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 293-participant average among 213 other Sickle Cell Disease trials with a reported enrollment target (83% lower).
The record links to 2 conditions, with Sickle Cell Disease appearing as the primary indexed condition, and to 2 interventions - of which Prophylactic Transfusion Intervention group: Transfusion is the first listed.
NCT06979492 reports a single indexed study location in Georgia.
Frequently Asked Questions
What is clinical trial NCT06979492 about?
NCT06979492 is a clinical study titled "Prophylactic Transfusion In Pregnant in Women With Sickle Cell Disease". The goal of this study is to determine if there is a positive effect of prophylactic red blood cell (RBC) transfusion of leukoreduced, ABO, Rh (D/Cc/Ee) and Kell matched blood compared to standard of care on the number of episodes of acute sickle cell disease (SCD) manifestations or pregnancy-relate...
What is the current status of trial NCT06979492?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 50 participants. The study started on 2026-04. Estimated completion is 2028-05.
What conditions does trial NCT06979492 study?
This clinical trial studies the following conditions: Sickle Cell Disease, Pregnancy Related.
What interventions are being tested in trial NCT06979492?
The interventions under investigation include: Prophylactic Transfusion Intervention group: Transfusion (BIOLOGICAL), Control group (OTHER).
Who is sponsoring clinical trial NCT06979492?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06979492 being conducted?
This trial has 1 study location across Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06979492's enrollment target sits among peer trials
50 106th of 213 higher than 100 of 213 other Sickle Cell Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Sickle Cell Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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