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NCT06976853 · ClinicalTrials.gov registry record · Phase 2
Moving Beyond Inflammation as a Therapeutic Target for Crohn's Disease
A Phase 2 study of Crohn Disease (CD), sponsored by Washington University School of Medicine.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
- 3
- Study locations
NCT06976853: Recruiting Phase 2 study of Crohn Disease (CD), sponsored by Washington University School of Medicine.
NCT06976853 is a Phase 2 study of Crohn Disease (CD) that is actively recruiting participants, run by Washington University School of Medicine. The registered enrollment target is 60 participants, below the 81-participant average among 5 other Crohn Disease (CD) trials with a reported enrollment target (26% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06976853, a Phase 2 study of Crohn Disease (CD), is actively recruiting participants, sponsored by Washington University School of Medicine.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
- 3
- Study locations
Study Summary
The purpose of this research study is to evaluate what type of treatment will be beneficial for people with Crohn's disease and difficult to treat inflammation in the small bowel. Current therapies are used to control the inflammation due to Crohn's disease in your digestive tract. In some patients, those therapies are not sufficient to fully treat the disease. This objective of this study is to evaluate the efficacy of a different type of therapy, tirzepatide, that may promote healing of the affected intestinal segment. To evaluate the efficacy of this medication, a member of the research team will ask patients questions about how they feel and observe whether this medication heals the their bowel at colonoscopy. A member of the research team will also use blood samples, stool samples and samples of the small intestine taken during a colonoscopy to understand how tirzepatide helps heal the intestine.
Conditions Studied
Interventions
- DRUG Tirzepatide
- DRUG Standard of care treatment
Study Locations (3)
California
- Cedars-Sinai Medical Center - Beverly Hills
Missouri
- Washington University School of Medicine - St Louis
New York
- Icahn School of Medicine at Mount Sinai - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2025-05-13 |
| Est. Completion | 2028-08 |
| Phase | Phase 2 |
What NCT06976853 shows while recruiting
NCT06976853 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 81-participant average among 5 other Crohn Disease (CD) trials with a reported enrollment target (26% lower).
The record links to 1 condition, with Crohn Disease (CD) appearing as the primary indexed condition, and to 2 interventions - of which Tirzepatide is the first listed.
NCT06976853 reports a single indexed study location in California, Missouri, New York.
Frequently Asked Questions
What is clinical trial NCT06976853 about?
NCT06976853 is a clinical study titled "Moving Beyond Inflammation as a Therapeutic Target for Crohn's Disease". The purpose of this research study is to evaluate what type of treatment will be beneficial for people with Crohn's disease and difficult to treat inflammation in the small bowel. Current therapies are used to control the inflammation due to Crohn's disease in your digestive tract. In some patients,...
What is the current status of trial NCT06976853?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2025-05-13. Estimated completion is 2028-08.
What conditions does trial NCT06976853 study?
This clinical trial studies the following conditions: Crohn Disease (CD).
What interventions are being tested in trial NCT06976853?
The interventions under investigation include: Tirzepatide (DRUG), Standard of care treatment (DRUG).
Who is sponsoring clinical trial NCT06976853?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06976853 being conducted?
This trial has 3 study locations across California, Missouri, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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