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NCT06976840 · ClinicalTrials.gov registry record · NA
Rapid Antidepressant Dynamics in Acute Neuromodulation Treatments
A NA study, sponsored by Marta Peciña, MD PhD.
- Recruiting
- Registry status
- NA
- Development phase
- 200
- Enrollment target
NCT06976840: Recruiting NA study, sponsored by Marta Peciña, MD PhD.
NCT06976840 is a NA study that is actively recruiting participants, run by Marta Peciña, MD PhD. The registered enrollment target is 200 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (86% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06976840, a NA study, is actively recruiting participants, sponsored by Marta Peciña, MD PhD.
- RECRUITING
- Registry status
- NA
- Development phase
- 200 participants
- Enrollment target
Study Summary
The goal of this clinical trial is to learn how different types of non-invasive brain stimulation affect mood and brain function in adults with major depressive disorder (MDD). It will also study how brain stimulation may work together with antidepressant treatments. The main questions this study aims to answer are: How do different patterns of brain stimulation affect mood in people with depression? Do brain networks involved in emotion and self-reflection respond differently depending on the type of stimulation? What are the combined effects of brain stimulation and antidepressant treatments on mood and brain activity? Researchers will compare different brain stimulation patterns and target areas to understand their individual and combined effects. Participants will: Receive three types of brain stimulation (intermittent, continuous, and sham) in different sessions Undergo MRI scans during the administration of either a fast-acting or conventional antidepressant. Complete mood assessments during the scan and for one week after each session This study may help identify brain-based strategies to improve treatment for depression. In addition, a subset of participants (\~10) will complete a reward-guided decision-making fMRI task for feasibility purposes.
Primary Outcome
Change in blood oxygenation level-dependent (BOLD) signal within the salience network (SN), measured during the fMRI experiment. Comparisons is made across transcranial magnetic stimulation conditions: intermittent theta burst stimulation (iTBS) vs. sham TBS (sTBS), and continuous TBS (cTBS) vs. sTBS. SN activation is assessed using fMRI contrasts sensitive to expectancy-induced neural modulation.
Interventions
- DEVICE Intermittent theta burst stimulation
- DEVICE Sham theta burst stimulation
- DEVICE Continuous theta burst stimulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2026-05-15 |
| Est. Completion | 2030-08-01 |
| Phase | NA |
What NCT06976840 shows while recruiting
NCT06976840 is an interventional study that assigns participants to a tested intervention. The registered 200 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (86% lower).
The record links to 0 conditions, and to 3 interventions - of which Intermittent theta burst stimulation is the first listed.
NCT06976840 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06976840 about?
NCT06976840 is a clinical study titled "Rapid Antidepressant Dynamics in Acute Neuromodulation Treatments". The goal of this clinical trial is to learn how different types of non-invasive brain stimulation affect mood and brain function in adults with major depressive disorder (MDD). It will also study how brain stimulation may work together with antidepressant treatments. The main questions this study a...
What is the current status of trial NCT06976840?
This trial is currently recruiting. It is a NA study. The enrollment target is 200 participants. The study started on 2026-05-15. Estimated completion is 2030-08-01.
What interventions are being tested in trial NCT06976840?
The interventions under investigation include: Intermittent theta burst stimulation (DEVICE), Sham theta burst stimulation (DEVICE), Continuous theta burst stimulation (DEVICE).
Who is sponsoring clinical trial NCT06976840?
This trial is sponsored by Marta Peciña, MD PhD, which has 4 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06976840's enrollment target sits among peer trials
200 506th of 2000 higher than 1,434 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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