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Frontline T-cell Engager vs Autologous Stem Cell Transplant (ASCT) and Measurable Residual Disease (MRD)-Guided Sequential Intensification thERapy in Multiple Myeloma
NCT06974786 · View on ClinicalTrials.gov ↗
Study Summary
This is an open-label, multi-site, Phase II randomized trial with response-adaptive design for newly diagnosed multiple myeloma (NDMM) participants who have had prior induction therapy. The primary objective of this study is to compare the rates of achieving undetectable measurable residual disease (MRD) in the bone marrow with elranatamab and daratumumab employed as post-induction consolidation and maintenance treatment (Arm A) versus autologous stem cell transplant (ASCT) followed by lenalidomide and daratumumab treatment (Arm B).
Conditions Studied
Interventions
- DRUG Lenalidomide
- DRUG Elranatamab
- DRUG Daratumumab
- PROCEDURE autologous stem cell transplantation
Study Locations (9)
Wisconsin
- University of Wisconsin Clinical Science Center — Madison
- Medical College of Wisconsin — Milwaukee
Alabama
- University of Alabama at Birmingham — Birmingham
Colorado
- Colorado Blood Cancer Institute — Denver
Iowa
- University of Iowa — Iowa City
North Carolina
- University of North Carolina — Chapel Hill
Ohio
- Oncology Hematology Care — Cincinnati
Tennessee
- SCRI Oncology Partners — Nashville
Virginia
- Virginia Oncology Associates — Norfolk
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2025-08-08 |
| Est. Completion | 2033-04 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06974786
The ClinicalTrials.gov registry entry for NCT06974786 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 100 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is SCRI Development Innovations, which has 63 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Multiple Myeloma (MM) appearing as the primary indexed condition, and to 4 interventions — of which Lenalidomide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06974786 reports 9 study locations spanning 8 distinct geographic areas — top geographies include Wisconsin, Alabama, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06974786 about?
NCT06974786 is a clinical study titled "Frontline T-cell Engager vs Autologous Stem Cell Transplant (ASCT) and Measurable Residual Disease (MRD)-Guided Sequential Intensification thERapy in Multiple Myeloma". This is an open-label, multi-site, Phase II randomized trial with response-adaptive design for newly diagnosed multiple myeloma (NDMM) participants who have had prior induction therapy. The primary objective of this study is to compare the rates of achieving undetectable measurable residual disease ...
What is the current status of trial NCT06974786?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 100 participants. The study started on 2025-08-08. Estimated completion is 2033-04.
What conditions does trial NCT06974786 study?
This clinical trial studies the following conditions: Multiple Myeloma (MM), Multiple Myeloma, Newly Diagnosed. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06974786?
The interventions under investigation include: Lenalidomide (DRUG), Elranatamab (DRUG), Daratumumab (DRUG), autologous stem cell transplantation (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06974786?
This trial is sponsored by SCRI Development Innovations, which has 63 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06974786 being conducted?
This trial has 9 study locations across Alabama, Colorado, Iowa, North Carolina, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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