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NCT07280013 · ClinicalTrials.gov registry record · Phase 1
A Study to Learn About the Effects of Cemsidomide in Combination With Elranatamab in Relapsed/Refractory Multiple Myeloma Subjects
A Phase 1 study of Multiple Myeloma (MM), sponsored by C4 Therapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 60
- Enrollment target
- 19
- Study locations
NCT07280013 is a Phase 1 study of Multiple Myeloma (MM) that is actively recruiting participants, run by C4 Therapeutics. The registered enrollment target is 60 participants. The trial reports 19 study locations across 17 states.
The verdict
NCT07280013, a Phase 1 study of Multiple Myeloma (MM), is actively recruiting participants, sponsored by C4 Therapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 60 participants
- Enrollment target
- 19
- Study locations
Study Summary
The main purpose of the study is to understand the safety and tolerability of cemsidomide when given along with elranatamab in subjects with relapsed or refractory multiple myeloma. The first part of the study will evaluate different dose levels of cemsidomide in combination with elranatamab in a limited number of subjects. Approximately 3 different dose levels of cemsidomide in combination with elranatamab may be explored. Once a dose level is determined safe, additional subjects may be enrolled through expansion of the dose level. This expansion will provide further exploration of the safety and evaluation of preliminary antimyeloma activity. Cemsidomide will be taken orally each cycle for 14 days on/14 days off (1 cycle=28 days). Elranatamab will be administered by subcutaneous injection twice a month. Dexamethasone will be administered weekly until a confirmed response but no longer than 4 cycles.
Conditions Studied
Interventions
- DRUG Cemsidomide
- BIOLOGICAL Elranatamab
Study Locations (19)
New York
- Perlmutter Cancer Center at NYU Langone Hospital - Brooklyn
- Memorial Sloan Kettering Cancer Center - New York
Texas
- Houston Methodist Hospital - Houston
- MD Anderson Cancer Center - Houston
Arizona
- Banner MD Anderson Cancer Center - Gilbert
California
- UCLA Health, Jonsson Comprehensive Cancer Center - Santa Monica
Florida
- Tampa General Hospital - Tampa
Georgia
- Winship Cancer Institute, Emory University - Atlanta
Illinois
- Loyola University Medical Center - Maywood
Indiana
- Indiana University - Indianapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2026-02-06 |
| Est. Completion | 2029-06 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07280013
The ClinicalTrials.gov registry entry for NCT07280013 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is C4 Therapeutics, which has 5 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Multiple Myeloma (MM) appearing as the primary indexed condition, and to 2 interventions - of which Cemsidomide is the first listed.
NCT07280013 reports 19 study locations spanning 17 distinct geographic areas - top geographies include New York, Texas, Arizona.
Frequently Asked Questions
What is clinical trial NCT07280013 about?
NCT07280013 is a clinical study titled "A Study to Learn About the Effects of Cemsidomide in Combination With Elranatamab in Relapsed/Refractory Multiple Myeloma Subjects". The main purpose of the study is to understand the safety and tolerability of cemsidomide when given along with elranatamab in subjects with relapsed or refractory multiple myeloma. The first part of the study will evaluate different dose levels of cemsidomide in combination with elranatamab in a l...
What is the current status of trial NCT07280013?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 60 participants. The study started on 2026-02-06. Estimated completion is 2029-06.
What conditions does trial NCT07280013 study?
This clinical trial studies the following conditions: Multiple Myeloma (MM).
What interventions are being tested in trial NCT07280013?
The interventions under investigation include: Cemsidomide (DRUG), Elranatamab (BIOLOGICAL).
Who is sponsoring clinical trial NCT07280013?
This trial is sponsored by C4 Therapeutics, which has 5 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07280013 being conducted?
This trial has 19 study locations across Arizona, California, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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