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RECRUITING Phase 1

A Study to Learn About the Effects of Cemsidomide in Combination With Elranatamab in Relapsed/Refractory Multiple Myeloma Subjects

NCT07280013 · View on ClinicalTrials.gov ↗

Study Summary

The main purpose of the study is to understand the safety and tolerability of cemsidomide when given along with elranatamab in subjects with relapsed or refractory multiple myeloma. The first part of the study will evaluate different dose levels of cemsidomide in combination with elranatamab in a limited number of subjects. Approximately 3 different dose levels of cemsidomide in combination with elranatamab may be explored. Once a dose level is determined safe, additional subjects may be enrolled through expansion of the dose level. This expansion will provide further exploration of the safety and evaluation of preliminary antimyeloma activity. Cemsidomide will be taken orally each cycle for 14 days on/14 days off (1 cycle=28 days). Elranatamab will be administered by subcutaneous injection twice a month. Dexamethasone will be administered weekly until a confirmed response but no longer than 4 cycles.

Conditions Studied

Interventions

  • DRUG Cemsidomide
  • BIOLOGICAL Elranatamab

Study Locations (19)

New York

  • Perlmutter Cancer Center at NYU Langone Hospital — Brooklyn
  • Memorial Sloan Kettering Cancer Center — New York

Texas

  • Houston Methodist Hospital — Houston
  • MD Anderson Cancer Center — Houston

Arizona

  • Banner MD Anderson Cancer Center — Gilbert

California

  • UCLA Health, Jonsson Comprehensive Cancer Center — Santa Monica

Florida

  • Tampa General Hospital — Tampa

Georgia

  • Winship Cancer Institute, Emory University — Atlanta

Illinois

  • Loyola University Medical Center — Maywood

Indiana

  • Indiana University — Indianapolis

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2026-02-06
Est. Completion 2029-06
Phase Phase 1

Sponsor

C4 Therapeutics

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07280013

The ClinicalTrials.gov registry entry for NCT07280013 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is C4 Therapeutics, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Multiple Myeloma (MM) appearing as the primary indexed condition, and to 2 interventions — of which Cemsidomide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07280013 reports 19 study locations spanning 17 distinct geographic areas — top geographies include New York, Texas, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07280013 about?

NCT07280013 is a clinical study titled "A Study to Learn About the Effects of Cemsidomide in Combination With Elranatamab in Relapsed/Refractory Multiple Myeloma Subjects". The main purpose of the study is to understand the safety and tolerability of cemsidomide when given along with elranatamab in subjects with relapsed or refractory multiple myeloma. The first part of the study will evaluate different dose levels of cemsidomide in combination with elranatamab in a l...

What is the current status of trial NCT07280013?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 60 participants. The study started on 2026-02-06. Estimated completion is 2029-06.

What conditions does trial NCT07280013 study?

This clinical trial studies the following conditions: Multiple Myeloma (MM). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07280013?

The interventions under investigation include: Cemsidomide (DRUG), Elranatamab (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07280013?

This trial is sponsored by C4 Therapeutics, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07280013 being conducted?

This trial has 19 study locations across Arizona, California, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial