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NCT06954675 · ClinicalTrials.gov registry record · NA
Comparison of Microbiome Changes in Healthy Adults Following Ketone Ester Consumption
A NA study of Microbiome Analysis, sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- NA
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT06954675: Recruiting NA study of Microbiome Analysis, sponsored by University of California, San Francisco.
NCT06954675 is a NA study of Microbiome Analysis that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 20 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06954675, a NA study of Microbiome Analysis, is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this observational study is to learn if a ketone ester can improve the content of the gut microbiome. The main questions it aims to answer are: * Does a ketone ester reduce age-related signatures in the gut microbiome? * What changes occur in the gut microbiome after consuming a ketone ester? Participants will: * Take a ketone ester every day for seven (7) days * Collect and ship stool samples within seven (7) days before, during, and within seven (7) days after the study period * Measure their ketone levels with a urine strip every day after having the drink * Answer questions about their typical diet on a normal day * Record their symptoms, if any arise
Primary Outcome
Microbiome composition will be defined as the following components: 1) alpha-diversity as calculated by Shannon Index; 2) beta-diversity; and 3) microbial community taxa and gene number.
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT Exogenous ketone ester
Study Locations (1)
California
- UCSF Wayne and Gladys Valley Center for Vision - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2025-11-21 |
| Est. Completion | 2026-09-30 |
| Phase | NA |
What NCT06954675 shows while recruiting
NCT06954675 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Microbiome Analysis appearing as the primary indexed condition, and to 1 intervention - of which Exogenous ketone ester is the first listed.
NCT06954675 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06954675 about?
NCT06954675 is a clinical study titled "Comparison of Microbiome Changes in Healthy Adults Following Ketone Ester Consumption". The goal of this observational study is to learn if a ketone ester can improve the content of the gut microbiome. The main questions it aims to answer are: * Does a ketone ester reduce age-related signatures in the gut microbiome? * What changes occur in the gut microbiome after consuming a ketone ...
What is the current status of trial NCT06954675?
This trial is currently recruiting. It is a NA study. The enrollment target is 20 participants. The study started on 2025-11-21. Estimated completion is 2026-09-30.
What conditions does trial NCT06954675 study?
This clinical trial studies the following conditions: Microbiome Analysis.
What interventions are being tested in trial NCT06954675?
The interventions under investigation include: Exogenous ketone ester (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT06954675?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06954675 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06954675's enrollment target sits among peer trials
20 1768th of 2000 higher than 140 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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