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NCT06953388 · ClinicalTrials.gov registry record · Phase 1
Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD
A Phase 1 study, sponsored by Wayne State University.
- Not yet
- Registry status
- Phase 1
- Development phase
- 60
- Enrollment target
NCT06953388: Clinical Trial Phase 1 study, sponsored by Wayne State University.
NCT06953388 is a Phase 1 study that has not yet begun recruiting, run by Wayne State University. The registered enrollment target is 60 participants, roughly in line with the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06953388, a Phase 1 study, has not yet begun recruiting, sponsored by Wayne State University.
- NOT YET RECRUITING
- Registry status
- Phase 1
- Development phase
- 60 participants
- Enrollment target
Study Summary
The goal of this study is to determine how non-invasive brain stimulation (delivered through the ear called vagus nerve stimulation) affects fear learning processes in people who have experienced psychological trauma. To answer these questions, we measure bodily responses (heart rate, sweat, startle) and questionnaires. The main questions it aims to answer are: Does non-invasive vagus nerve stimulation help reduce anxious arousal? Does non-invasive vagus nerve stimulation help dampen learned fear?
Primary Outcome
FPS modulation, an objective behavioral indicator of defensive reactivity, is measured during acquisition and extinction, collected using electromyogram (EMG) of the right orbicularis oculi muscle with the EMG module of the Biopac MP160 for Windows.
Interventions
- DEVICE transcutaneous auricular vagus nerve stimulation
- DEVICE sham transcutaneous auricular vagus nerve stimulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2026-02-01 |
| Est. Completion | 2032-12 |
| Phase | Phase 1 |
What is known before NCT06953388 opens enrollment
NCT06953388 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, roughly in line with the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target.
The record links to 0 conditions, and to 2 interventions - of which transcutaneous auricular vagus nerve stimulation is the first listed.
NCT06953388 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06953388 about?
NCT06953388 is a clinical study titled "Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD". The goal of this study is to determine how non-invasive brain stimulation (delivered through the ear called vagus nerve stimulation) affects fear learning processes in people who have experienced psychological trauma. To answer these questions, we measure bodily responses (heart rate, sweat, startle...
What is the current status of trial NCT06953388?
This trial is currently not yet recruiting. It is a Phase 1 study. The enrollment target is 60 participants. The study started on 2026-02-01. Estimated completion is 2032-12.
What interventions are being tested in trial NCT06953388?
The interventions under investigation include: transcutaneous auricular vagus nerve stimulation (DEVICE), sham transcutaneous auricular vagus nerve stimulation (DEVICE).
Who is sponsoring clinical trial NCT06953388?
This trial is sponsored by Wayne State University, which has 163 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06953388's enrollment target sits among peer trials
60 831st of 2000 higher than 1,106 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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