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NCT06950060 · ClinicalTrials.gov registry record · NA
AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions
A NA study, sponsored by University of Alabama at Birmingham.
- Not yet
- Registry status
- NA
- Development phase
- 48
- Enrollment target
NCT06950060: Clinical Trial NA study, sponsored by University of Alabama at Birmingham.
NCT06950060 is a NA study that has not yet begun recruiting, run by University of Alabama at Birmingham. The registered enrollment target is 48 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06950060, a NA study, has not yet begun recruiting, sponsored by University of Alabama at Birmingham.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 48 participants
- Enrollment target
Study Summary
The AMPLIFI study (Adaptive Modulation of Plasticity through Lactate and Fitness Interventions) investigates how short-term aerobic exercise influences brain plasticity and learning in older adults and stroke survivors. The study compares three groups: one performing aerobic cycling at an intensity that elevates lactate levels, one performing low-intensity exercise, and one receiving health education without exercise. All participants will complete motor learning tasks and undergo brain-stimulation testing using transcranial magnetic stimulation (TMS) to assess how well the brain responds to training. The goal is to understand whether different types of exercise can improve brain function, movement, and memory, and how the body's response to exercise (like lactate levels) might support brain health. This research may help identify low-cost, non-invasive interventions-such as targeted exercise-that improve motor and cognitive outcomes in aging and stroke recovery.
Primary Outcome
Motor learning is assessed using the 12-digit Serial Reaction Time Task (SRTT), a computer-based measure of implicit motor sequence learning. Participants respond to visual cues by pressing buttons in a fixed or random sequence. Learning is quantified by changes in reaction time and accuracy across structured and unstructured trials. A learning index is derived by comparing performance between patterned (learning) and random sequences.
Interventions
- BEHAVIORAL Moderate Intensity Aerobic Exercise
- BEHAVIORAL High intensity cycling
- BEHAVIORAL Low-intensity cycling
- BEHAVIORAL Health education session
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2026-05-14 |
| Est. Completion | 2030-01-01 |
| Phase | NA |
What is known before NCT06950060 opens enrollment
NCT06950060 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 4 interventions - of which Moderate Intensity Aerobic Exercise is the first listed.
NCT06950060 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06950060 about?
NCT06950060 is a clinical study titled "AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions". The AMPLIFI study (Adaptive Modulation of Plasticity through Lactate and Fitness Interventions) investigates how short-term aerobic exercise influences brain plasticity and learning in older adults and stroke survivors. The study compares three groups: one performing aerobic cycling at an intensity ...
What is the current status of trial NCT06950060?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 48 participants. The study started on 2026-05-14. Estimated completion is 2030-01-01.
What interventions are being tested in trial NCT06950060?
The interventions under investigation include: Moderate Intensity Aerobic Exercise (BEHAVIORAL), High intensity cycling (BEHAVIORAL), Low-intensity cycling (BEHAVIORAL), Health education session (BEHAVIORAL).
Who is sponsoring clinical trial NCT06950060?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06950060's enrollment target sits among peer trials
48 1381st of 2000 higher than 601 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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