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NCT06949644 · ClinicalTrials.gov registry record · NA
Pupillometry in Delayed Sleep Wake Phase Disorder
A NA study, sponsored by Northwestern University.
- Recruiting
- Registry status
- NA
- Development phase
- 220
- Enrollment target
NCT06949644: Recruiting NA study, sponsored by Northwestern University.
NCT06949644 is a NA study that is actively recruiting participants, run by Northwestern University. The registered enrollment target is 220 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (84% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06949644, a NA study, is actively recruiting participants, sponsored by Northwestern University.
- RECRUITING
- Registry status
- NA
- Development phase
- 220 participants
- Enrollment target
Study Summary
The goal of this observational study is to characterize the pupil light response in patients with delayed sleep-wake phase disorder. A subset of participants will take part in a clinical trial to determine if increasing serotonin can alter the circadian response to light. The main questions it aims to answer is: Are there differences in the light response in patients with delayed sleep-wake phase disorder? Does citalopram increase melatonin suppression in patients with delayed sleep-wake phase disorder? Participants will complete activity and melatonin testing at home to determine their circadian timing. This will be followed by an eye test looking at the pupil response to different light stimuli. A subset of participants will complete two inpatient admissions where melatonin levels will be sampled and they will be exposed to a bright light. During one round of testing they will receive a placebo and in the other round of testing they will take a single dose of citalopram, a selective serotonin reuptake inhibitor.
Primary Outcome
Saliva melatonin samples will be collected before and after light exposure
Interventions
- COMBINATION_PRODUCT Light and Citalopram
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 220 participants |
| Start Date | 2025-09-01 |
| Est. Completion | 2029-08-31 |
| Phase | NA |
What NCT06949644 shows while recruiting
NCT06949644 is an interventional study that assigns participants to a tested intervention. The registered 220 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (84% lower).
The record links to 0 conditions, and to 1 intervention - of which Light and Citalopram is the first listed.
NCT06949644 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06949644 about?
NCT06949644 is a clinical study titled "Pupillometry in Delayed Sleep Wake Phase Disorder". The goal of this observational study is to characterize the pupil light response in patients with delayed sleep-wake phase disorder. A subset of participants will take part in a clinical trial to determine if increasing serotonin can alter the circadian response to light. The main questions it aims ...
What is the current status of trial NCT06949644?
This trial is currently recruiting. It is a NA study. The enrollment target is 220 participants. The study started on 2025-09-01. Estimated completion is 2029-08-31.
What interventions are being tested in trial NCT06949644?
The interventions under investigation include: Light and Citalopram (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT06949644?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06949644's enrollment target sits among peer trials
220 481st of 2000 higher than 1,516 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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