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NCT06949072 · ClinicalTrials.gov registry record · NA
A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries
A NA study, sponsored by HALEON.
- Completed
- Registry status
- NA
- Development phase
- 47
- Enrollment target
NCT06949072: Completed NA study, sponsored by HALEON.
NCT06949072 is a NA study that has completed, run by HALEON. The registered enrollment target is 47 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06949072, a NA study, has completed, sponsored by HALEON.
- COMPLETED
- Registry status
- NA
- Development phase
- 47 participants
- Enrollment target
Study Summary
The aim of this study is to evaluate the relative efficacy of an experimental dentifrice containing 1150 parts per million (ppm) fluoride (as sodium fluoride \[NaF\]) to remineralize early stage caries type lesions in an in situ model compared to a negative control and a reference dentifrice.
Primary Outcome
The Surface Microhardness (SMH) technique is used to detect changes in the mineral content of dental enamel. The %SMHr will be derived as \[(D1-R)/(D1-B)\]\*100, where D1= mean of replicate indentation lengths (micrometer \[μm\]) in enamel after first in vitro demineralization, R= mean of replicate indentation lengths (μm) in enamel after 2-weeks in situ and B= mean of replicate indentation lengths (μm) in sound enamel at baseline.
Interventions
- DRUG Test Dentifrice
- DRUG Reference Dentifrice
- DRUG Negative Control Dentifrice
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 47 participants |
| Start Date | 2025-04-28 |
| Est. Completion | 2025-09-11 |
| Phase | NA |
What the finished NCT06949072 record still lists
NCT06949072 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 47 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 3 interventions - of which Test Dentifrice is the first listed.
NCT06949072 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06949072 about?
NCT06949072 is a clinical study titled "A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries". The aim of this study is to evaluate the relative efficacy of an experimental dentifrice containing 1150 parts per million (ppm) fluoride (as sodium fluoride \[NaF\]) to remineralize early stage caries type lesions in an in situ model compared to a negative control and a reference dentifrice.
What is the current status of trial NCT06949072?
This trial is currently completed. It is a NA study. The enrollment target is 47 participants. The study started on 2025-04-28. Estimated completion is 2025-09-11.
What interventions are being tested in trial NCT06949072?
The interventions under investigation include: Test Dentifrice (DRUG), Reference Dentifrice (DRUG), Negative Control Dentifrice (DRUG).
Who is sponsoring clinical trial NCT06949072?
This trial is sponsored by HALEON, which has 34 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06949072's enrollment target sits among peer trials
47 1400th of 2000 higher than 599 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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