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NCT06930651 · ClinicalTrials.gov registry record · Phase 1
A Phase I/II Study of CAR.70-Engineered IL15-Transduced Cord Blood-Derived NK Cells With TGF-beta Receptor 2 (TGFBR2) Knock Out in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapsed/Refractory Myeloid Malignancies
A Phase 1 study of Myeloid Malignancies, sponsored by M.D. Anderson Cancer Center.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 42
- Enrollment target
- 1
- Study location
NCT06930651 is a Phase 1 study of Myeloid Malignancies that is actively recruiting participants, run by M.D. Anderson Cancer Center. The registered enrollment target is 42 participants, roughly in line with the 43-participant average among 5 other Myeloid Malignancies trials with a reported enrollment target. The trial reports 1 study location across 1 state.
The verdict
NCT06930651, a Phase 1 study of Myeloid Malignancies, is actively recruiting participants, sponsored by M.D. Anderson Cancer Center.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 42 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical research study is to find the recommended safe dose of TGFBR2 KO CAR27/IL-15 NK cells that can be given to patients with relapsed/refractory disease. The safety and effectiveness of this treatment will also be studied.
Conditions Studied
Interventions
- DRUG Cyclophosphamide
- DRUG Fludarabine
- DRUG Decitabine
- DRUG Dexamethasone
- BIOLOGICAL TGFBR2 KO CAR27/IL-15 NK cells
Study Locations (1)
Texas
- The University of Texas M. D. Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 42 participants |
| Start Date | 2025-09-03 |
| Est. Completion | 2030-05-01 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06930651
The ClinicalTrials.gov registry entry for NCT06930651 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 42 participants, a figure that helps gauge the scale of data the investigators plan to collect, roughly in line with the 43-participant average among 5 other Myeloid Malignancies trials with a reported enrollment target. The listed sponsor is M.D. Anderson Cancer Center, which has 2,692 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Myeloid Malignancies appearing as the primary indexed condition, and to 5 interventions - of which Cyclophosphamide is the first listed.
NCT06930651 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.
Frequently Asked Questions
What is clinical trial NCT06930651 about?
NCT06930651 is a clinical study titled "A Phase I/II Study of CAR.70-Engineered IL15-Transduced Cord Blood-Derived NK Cells With TGF-beta Receptor 2 (TGFBR2) Knock Out in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapsed/Refractory Myeloid Malignancies". The goal of this clinical research study is to find the recommended safe dose of TGFBR2 KO CAR27/IL-15 NK cells that can be given to patients with relapsed/refractory disease. The safety and effectiveness of this treatment will also be studied.
What is the current status of trial NCT06930651?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 42 participants. The study started on 2025-09-03. Estimated completion is 2030-05-01.
What conditions does trial NCT06930651 study?
This clinical trial studies the following conditions: Myeloid Malignancies.
What interventions are being tested in trial NCT06930651?
The interventions under investigation include: Cyclophosphamide (DRUG), Fludarabine (DRUG), Decitabine (DRUG), Dexamethasone (DRUG), TGFBR2 KO CAR27/IL-15 NK cells (BIOLOGICAL).
Who is sponsoring clinical trial NCT06930651?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06930651 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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