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NCT06910241 · ClinicalTrials.gov registry record · Phase 3
Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration Repairs
A Phase 3 study of Laceration of Skin, sponsored by Florida Atlantic University.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT06910241: Recruiting Phase 3 study of Laceration of Skin, sponsored by Florida Atlantic University.
NCT06910241 is a Phase 3 study of Laceration of Skin that is actively recruiting participants, run by Florida Atlantic University. The registered enrollment target is 100 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (87% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06910241, a Phase 3 study of Laceration of Skin, is actively recruiting participants, sponsored by Florida Atlantic University.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
Diphenhydramine, when injected locally, has been shown to achieve a certain level of local anesthesia. It has been documented for use in simple bedside procedures, however there is a gap in knowledge in its comparison to lidocaine. The purpose of the study is to determine if local infiltration of diphenhydramine is noninferior to the use of lidocaine 1% when trying to achieve local anesthesia for simple laceration repair. Patients who present to the emergency department with a simple laceration will be enrolled in the study. Patients will be evaluated for the pain of the injection as well as the pain of the laceration repair procedure post injection.
Primary Outcome
Participants will rate their sensation level on a visual analog scale from 0 to 10 both before the drug injection and after the laceration repair procedure. 0 indicating no sensation and 10 indicating worst sensation. Reduction in sensation will be calculated as the difference between the pre-injection and post-procedure sensation, with a larger number indicating a greater reduction in sensation.
Conditions Studied
Interventions
- DRUG Lidocaine
- DRUG Diphenhydramine
Study Locations (1)
Florida
- Bethesda Hospital East - Boynton Beach
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2025-09-03 |
| Est. Completion | 2028-06-30 |
| Phase | Phase 3 |
What NCT06910241 shows while recruiting
NCT06910241 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (87% lower).
The record links to 1 condition, with Laceration of Skin appearing as the primary indexed condition, and to 2 interventions - of which Lidocaine is the first listed.
NCT06910241 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT06910241 about?
NCT06910241 is a clinical study titled "Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration Repairs". Diphenhydramine, when injected locally, has been shown to achieve a certain level of local anesthesia. It has been documented for use in simple bedside procedures, however there is a gap in knowledge in its comparison to lidocaine. The purpose of the study is to determine if local infiltration of di...
What is the current status of trial NCT06910241?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 100 participants. The study started on 2025-09-03. Estimated completion is 2028-06-30.
What conditions does trial NCT06910241 study?
This clinical trial studies the following conditions: Laceration of Skin.
What interventions are being tested in trial NCT06910241?
The interventions under investigation include: Lidocaine (DRUG), Diphenhydramine (DRUG).
Who is sponsoring clinical trial NCT06910241?
This trial is sponsored by Florida Atlantic University, which has 27 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06910241 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Laceration of Skin
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06910241's enrollment target sits among peer trials
100 1682nd of 2000 higher than 288 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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