Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 2

A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide

NCT06897475 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to measure the change in hemoglobin A1c (HbA1c) with LY3457263 compared with placebo in participants with type 2 diabetes who are not at HbA1c goal when treated with a stable dose of semaglutide or tirzepatide. Participation in the study will last about 9 months.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG LY3457263

Study Locations (20)

Texas

  • Juno Research — Houston
  • Southern Endocrinology Associates — Mesquite
  • Texas Diabetes & Endocrinology, P.A. — Round Rock
  • Consano Clinical Research, LLC — Shavano Park
  • Texas Valley Clinical Research — Weslaco

Florida

  • Renstar Medical Research — Ocala
  • Oviedo Medical Research — Oviedo

Georgia

  • Balanced Life Health Care Solutions/SKYCRNG — Lawrenceville
  • Rophe Adult and Pediatric Medicine/SKYCRNG — Union City

New York

  • Richmond University Medical Center — Staten Island
  • Southgate Medical Group — West Seneca

North Carolina

  • Lucas Research, Inc. — Morehead City
  • Shelby Clinical Research — Shelby

Arizona

  • Helios Clinical Research - Phoenix — Phoenix

California

  • Wolverine Clinical Trials — Santa Ana

Idaho

  • Elite Clinical Trials — Rexburg

Trial Details

FieldValue
Enrollment Target 240 participants
Start Date 2025-03-28
Est. Completion 2027-01
Phase Phase 2

Sponsor

Eli Lilly and Company

704 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06897475

The ClinicalTrials.gov registry entry for NCT06897475 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 240 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Type 2 Diabetes appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06897475 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Texas, Florida, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06897475 about?

NCT06897475 is a clinical study titled "A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide". The purpose of this study is to measure the change in hemoglobin A1c (HbA1c) with LY3457263 compared with placebo in participants with type 2 diabetes who are not at HbA1c goal when treated with a stable dose of semaglutide or tirzepatide. Participation in the study will last about 9 months.

What is the current status of trial NCT06897475?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 240 participants. The study started on 2025-03-28. Estimated completion is 2027-01.

What conditions does trial NCT06897475 study?

This clinical trial studies the following conditions: Type 2 Diabetes. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06897475?

The interventions under investigation include: Placebo (DRUG), LY3457263 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06897475?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06897475 being conducted?

This trial has 20 study locations across Arizona, California, Florida, Georgia, Idaho. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial