Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 3

ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

NCT06876714 · View on ClinicalTrials.gov ↗

Study Summary

This phase III trial compares 6 months of human epidermal growth factor receptor 2 (HER2)-targeted therapy to 12 months of HER2-targeted therapy for the treatment of HER2-positive (+) breast cancer in patients that had a pathologic complete response (pCR) after preoperative (neoadjuvant) chemotherapy with trastuzumab. Trastuzumab and pertuzumab are monoclonal antibodies and forms of targeted therapy that attach to a receptor protein called HER2. HER2 is found on some cancer cells. When trastuzumab or pertuzumab attach to HER2, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body's immune system. Giving 6 months of HER2-targeted therapy may work better than giving 12 months for the treatment of HER2+ breast cancer in patients that had a pCR after neoadjuvant chemotherapy with trastuzumab.

Interventions

  • PROCEDURE Echocardiography
  • PROCEDURE Multigated Acquisition Scan
  • PROCEDURE Mammography
  • BIOLOGICAL Trastuzumab (Herceptin)
  • BIOLOGICAL Pertuzumab

Study Locations (20)

California

  • Mission Hope Medical Oncology - Arroyo Grande — Arroyo Grande
  • Mercy Cancer Center - Carmichael — Carmichael
  • Mercy San Juan Medical Center — Carmichael
  • Enloe Medical Center — Chico
  • Kaiser Permanente Dublin — Dublin
  • Mercy Cancer Center - Elk Grove — Elk Grove
  • Kaiser Permanente-Fremont — Fremont
  • Kaiser Permanente Fresno Orchard Plaza — Fresno
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care — Irvine
  • UC San Diego Moores Cancer Center — La Jolla
  • Fremont - Rideout Cancer Center — Marysville
  • Mercy Cancer Center — Merced
  • Kaiser Permanente- Modesto MOB II — Modesto
  • Kaiser Permanente-Modesto — Modesto
  • Kaiser Permanente-Oakland — Oakland
  • UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange
  • Mercy Cancer Center - Rocklin — Rocklin

Arkansas

  • Mercy Hospital Fort Smith — Fort Smith
  • CARTI Cancer Center — Little Rock

Arizona

  • Cancer Center at Saint Joseph's — Phoenix

Trial Details

FieldValue
Enrollment Target 1,524 participants
Start Date 2025-09-17
Est. Completion 2037-03-13
Phase Phase 3

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06876714

The ClinicalTrials.gov registry entry for NCT06876714 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,524 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Alliance for Clinical Trials in Oncology, which has 147 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Anatomic Stage II Breast Cancer AJCC v8 appearing as the primary indexed condition, and to 5 interventions — of which Echocardiography is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06876714 reports 20 study locations spanning 3 distinct geographic areas — top geographies include California, Arkansas, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06876714 about?

NCT06876714 is a clinical study titled "ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab". This phase III trial compares 6 months of human epidermal growth factor receptor 2 (HER2)-targeted therapy to 12 months of HER2-targeted therapy for the treatment of HER2-positive (+) breast cancer in patients that had a pathologic complete response (pCR) after preoperative (neoadjuvant) chemotherap...

What is the current status of trial NCT06876714?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 1,524 participants. The study started on 2025-09-17. Estimated completion is 2037-03-13.

What conditions does trial NCT06876714 study?

This clinical trial studies the following conditions: Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Early Stage Breast Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06876714?

The interventions under investigation include: Echocardiography (PROCEDURE), Multigated Acquisition Scan (PROCEDURE), Mammography (PROCEDURE), Trastuzumab (Herceptin) (BIOLOGICAL), Pertuzumab (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06876714?

This trial is sponsored by Alliance for Clinical Trials in Oncology, which has 147 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06876714 being conducted?

This trial has 20 study locations across Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial