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NCT06835504 · ClinicalTrials.gov registry record · Phase 3
Morphine or Ketamine for Analgesia
A Phase 3 study, sponsored by Columbia University.
- Not yet
- Registry status
- Phase 3
- Development phase
- 1,010
- Enrollment target
NCT06835504: Clinical Trial Phase 3 study, sponsored by Columbia University.
NCT06835504 is a Phase 3 study that has not yet begun recruiting, run by Columbia University. The registered enrollment target is 1,010 participants, above the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (31% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06835504, a Phase 3 study, has not yet begun recruiting, sponsored by Columbia University.
- NOT YET RECRUITING
- Registry status
- Phase 3
- Development phase
- 1,010 participants
- Enrollment target
Study Summary
Pain is common in children presenting to the emergency department but is frequently undertreated, leading to both short- and long-term consequences. Morphine is the standard treatment for children with moderate to severe acute pain, but its use is associated with serious side effects and caregiver and clinician concerns related to opioid administration. The investigators aim to determine if sub-dissociative ketamine is non-inferior to morphine for treating acute pain and a preferable alternative for treating acute pain in children because of its more favorable side effect profile and potential long-term benefits related to pain-related function, analgesic use/misuse, and mental and behavioral health outcomes.
Primary Outcome
Self-reported pain intensity measured using the Verbal Numerical Rating Scale (VNRS). Scored from 0 to 10. A higher score indicates a worse outcome.
Interventions
- DRUG Ketamine hydrochloride
- DRUG Morphine sulphate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,010 participants |
| Start Date | 2026-09-01 |
| Est. Completion | 2030-02-28 |
| Phase | Phase 3 |
What is known before NCT06835504 opens enrollment
NCT06835504 is an interventional study that assigns participants to a tested intervention. Its 1,010 participants enrollment target places it among the larger protocols in the corpus, above the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (31% higher).
The record links to 0 conditions, and to 2 interventions - of which Ketamine hydrochloride is the first listed.
NCT06835504 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06835504 about?
NCT06835504 is a clinical study titled "Morphine or Ketamine for Analgesia". Pain is common in children presenting to the emergency department but is frequently undertreated, leading to both short- and long-term consequences. Morphine is the standard treatment for children with moderate to severe acute pain, but its use is associated with serious side effects and caregiver a...
What is the current status of trial NCT06835504?
This trial is currently not yet recruiting. It is a Phase 3 study. The enrollment target is 1,010 participants. The study started on 2026-09-01. Estimated completion is 2030-02-28.
What interventions are being tested in trial NCT06835504?
The interventions under investigation include: Ketamine hydrochloride (DRUG), Morphine sulphate (DRUG).
Who is sponsoring clinical trial NCT06835504?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06835504's enrollment target sits among peer trials
1,010 295th of 2000 higher than 1,706 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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