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NCT06807918 · ClinicalTrials.gov registry record · Phase 2
Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder
A Phase 2 study, sponsored by University of Pennsylvania.
- Not yet
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
NCT06807918: Clinical Trial Phase 2 study, sponsored by University of Pennsylvania.
NCT06807918 is a Phase 2 study that has not yet begun recruiting, run by University of Pennsylvania. The registered enrollment target is 60 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (55% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06807918, a Phase 2 study, has not yet begun recruiting, sponsored by University of Pennsylvania.
- NOT YET RECRUITING
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
Study Summary
This is a randomized, double-blind, crossover trial to evaluate the immediate effects of a nutritional ketone supplement, Kenotic compared to placebo on brain function and alcohol consumption in individuals with alcohol use disorder. Participants will complete 2 MRI scans, 2 FDG PET/CT scans, and 2 alcohol bar labs and will randomly receive Kenetik at one lab and the placebo at the next lab. During the bar labs participants will consume a dose of alcohol (based on weight), to bring their breath alcohol concentration to about 0.050%.
Primary Outcome
The primary outcome measure to be analyzed is a comparison of a single dose of KS versus placebo in AUD subjects in the amount of FDG uptake (CMRg metabolic rate of glucose) (mmol/L) levels in the brain.
Interventions
- DIETARY_SUPPLEMENT Kenetik
- OTHER Placebo beverage
- OTHER magnetic resonance imaging scan
- OTHER fludeoxyglucose-18 positron emission tomography scan
- OTHER Alcohol bar lab
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2026-08-01 |
| Est. Completion | 2030-01-01 |
| Phase | Phase 2 |
What is known before NCT06807918 opens enrollment
NCT06807918 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (55% lower).
The record links to 0 conditions, and to 5 interventions - of which Kenetik is the first listed.
NCT06807918 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06807918 about?
NCT06807918 is a clinical study titled "Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder". This is a randomized, double-blind, crossover trial to evaluate the immediate effects of a nutritional ketone supplement, Kenotic compared to placebo on brain function and alcohol consumption in individuals with alcohol use disorder. Participants will complete 2 MRI scans, 2 FDG PET/CT scans, and 2 ...
What is the current status of trial NCT06807918?
This trial is currently not yet recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2026-08-01. Estimated completion is 2030-01-01.
What interventions are being tested in trial NCT06807918?
The interventions under investigation include: Kenetik (DIETARY_SUPPLEMENT), Placebo beverage (OTHER), magnetic resonance imaging scan (OTHER), fludeoxyglucose-18 positron emission tomography scan (OTHER), Alcohol bar lab (OTHER).
Who is sponsoring clinical trial NCT06807918?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06807918's enrollment target sits among peer trials
60 1027th of 2000 higher than 868 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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