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NCT06799247 · ClinicalTrials.gov registry record · Phase 3
Investigating an mRNA CAR T-cell Therapy, Known as Descartes-08, as a Potential Approach to Treat Myasthenia Gravis
A Phase 3 study of Myasthaenia Gravis, sponsored by Cartesian Therapeutics.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 100
- Enrollment target
- 20
- Study locations
NCT06799247 is a Phase 3 study of Myasthaenia Gravis that is actively recruiting participants, run by Cartesian Therapeutics. The registered enrollment target is 100 participants. The trial reports 20 study locations across 14 states.
The verdict
NCT06799247, a Phase 3 study of Myasthaenia Gravis, is actively recruiting participants, sponsored by Cartesian Therapeutics.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 100 participants
- Enrollment target
- 20
- Study locations
Study Summary
The AURORA Study is evaluating the safety, tolerability, and efficacy of an investigational mRNA CAR T-cell therapy known as Descartes-08 in adults with acetylcholine receptor autoantibody -positive generalized myasthenia gravis. Part 1 of the study will last around 6 months. For eligible participants, Part 2 will last around 8 months.
Conditions Studied
Interventions
- BIOLOGICAL Decartes-08
- OTHER Placebo Drug
Study Locations (20)
California
- A13 - Carlsbad
- A14 - Orange
Florida
- A48 - Maitland
- A10 - Tampa
New York
- A12 - Amherst
- A47 - New York
North Carolina
- A22 - Chapel Hill
- A39 - Charlotte
Pennsylvania
- A11 - Philadelphia
- A49 - Pittsburgh
Other
- A23 - Rome
- A30 - Krakow
Arizona
- A40 - Tucson
Colorado
- A21 - Aurora
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2025-05-06 |
| Est. Completion | 2027-09-30 |
| Phase | Phase 3 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06799247
The ClinicalTrials.gov registry entry for NCT06799247 describes a study currently listed as recruiting, categorized as Phase 3. The registered enrollment target is 100 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Cartesian Therapeutics, which has 12 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Myasthaenia Gravis appearing as the primary indexed condition, and to 2 interventions - of which Decartes-08 is the first listed.
NCT06799247 reports 20 study locations spanning 14 distinct geographic areas - top geographies include California, Florida, New York.
Frequently Asked Questions
What is clinical trial NCT06799247 about?
NCT06799247 is a clinical study titled "Investigating an mRNA CAR T-cell Therapy, Known as Descartes-08, as a Potential Approach to Treat Myasthenia Gravis". The AURORA Study is evaluating the safety, tolerability, and efficacy of an investigational mRNA CAR T-cell therapy known as Descartes-08 in adults with acetylcholine receptor autoantibody -positive generalized myasthenia gravis. Part 1 of the study will last around 6 months. For eligible participan...
What is the current status of trial NCT06799247?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 100 participants. The study started on 2025-05-06. Estimated completion is 2027-09-30.
What conditions does trial NCT06799247 study?
This clinical trial studies the following conditions: Myasthaenia Gravis.
What interventions are being tested in trial NCT06799247?
The interventions under investigation include: Decartes-08 (BIOLOGICAL), Placebo Drug (OTHER).
Who is sponsoring clinical trial NCT06799247?
This trial is sponsored by Cartesian Therapeutics, which has 12 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06799247 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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