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NCT06795659 · ClinicalTrials.gov registry record · Phase 1
Combining Esketamine and Prolonged Exposure Treatment for PTSD (Post Traumatic Stress Disorder)
A Phase 1 study, sponsored by The University of Texas Health Science Center at San Antonio.
- Completed
- Registry status
- Phase 1
- Development phase
- 4
- Enrollment target
NCT06795659: Completed Phase 1 study, sponsored by The University of Texas Health Science Center at San Antonio.
NCT06795659 is a Phase 1 study that has completed, run by The University of Texas Health Science Center at San Antonio. The registered enrollment target is 4 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (93% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06795659, a Phase 1 study, has completed, sponsored by The University of Texas Health Science Center at San Antonio.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 4 participants
- Enrollment target
Study Summary
This study is being done to see if Prolonged Exposure (PE), a well-researched, very effective individual (one-to-one) behavioral therapy designed to help people to directly deal with traumatic events they have suffered in the past, can be combined with intranasal esketamine (ketamine) for the treatment of posttraumatic stress disorder (PTSD) to enhance treatment benefits. Ketamine nasal spray is a drug approved by the U.S. Food \& Drug Administration (FDA) for treatment resistant depression. Combined with PE, intranasal ketamine may help to augment PE and further reduce participants' PTSD symptoms.
Primary Outcome
Number of eligible referrals
Interventions
- BEHAVIORAL Massed Prolonged Exposure (PE)
- DRUG Esketamine (Intranasal Spray)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 4 participants |
| Start Date | 2025-06-09 |
| Est. Completion | 2026-01-16 |
| Phase | Phase 1 |
What the finished NCT06795659 record still lists
NCT06795659 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 4 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (93% lower).
The record links to 0 conditions, and to 2 interventions - of which Massed Prolonged Exposure (PE) is the first listed.
NCT06795659 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06795659 about?
NCT06795659 is a clinical study titled "Combining Esketamine and Prolonged Exposure Treatment for PTSD (Post Traumatic Stress Disorder)". This study is being done to see if Prolonged Exposure (PE), a well-researched, very effective individual (one-to-one) behavioral therapy designed to help people to directly deal with traumatic events they have suffered in the past, can be combined with intranasal esketamine (ketamine) for the treatm...
What is the current status of trial NCT06795659?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 4 participants. The study started on 2025-06-09. Estimated completion is 2026-01-16.
What interventions are being tested in trial NCT06795659?
The interventions under investigation include: Massed Prolonged Exposure (PE) (BEHAVIORAL), Esketamine (Intranasal Spray) (DRUG).
Who is sponsoring clinical trial NCT06795659?
This trial is sponsored by The University of Texas Health Science Center at San Antonio, which has 378 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06795659's enrollment target sits among peer trials
4 1995th of 2000 higher than 2 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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