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NCT06738407 · ClinicalTrials.gov registry record · Phase 4
Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections
A Phase 4 study, sponsored by Westat.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 760
- Enrollment target
NCT06738407: Recruiting Phase 4 study, sponsored by Westat.
NCT06738407 is a Phase 4 study that is actively recruiting participants, run by Westat. The registered enrollment target is 760 participants, above the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (47% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06738407, a Phase 4 study, is actively recruiting participants, sponsored by Westat.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 760 participants
- Enrollment target
Study Summary
The goal of this open-label, randomized trial is to assess the efficacy of doxycycline prophylaxis in reducing incidences of bacterial sexually transmitted infections (STIs) among adolescent and young adult females while also evaluating acceptability and antimicrobial resistance in order to inform public health policy.
Primary Outcome
Overall combined incidence of GC, CT, and/or early syphilis infection by laboratory-based diagnosis (defined as positive GC or CT on nucleic acid amplification test \[NAAT\] or first positive rapid plasma reagin \[RPR\] with positive treponemal-specific antibody \[Ab\] or a new 4-fold rise in RPR titers) over the duration of follow-up.
Interventions
- DRUG Doxycycline hyclate delayed released 200 mg
- DRUG Doxycycline hyclate delayed released 200 mg weekly
- OTHER Per standard of care with quarterly STI testing/treatment and sexual health counseling
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 760 participants |
| Start Date | 2026-02-27 |
| Est. Completion | 2028-06-15 |
| Phase | Phase 4 |
What NCT06738407 shows while recruiting
NCT06738407 is an interventional study that assigns participants to a tested intervention. The registered 760 participants enrollment target is mid-sized for trials with a published cap, above the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (47% higher).
The record links to 0 conditions, and to 3 interventions - of which Doxycycline hyclate delayed released 200 mg is the first listed.
NCT06738407 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06738407 about?
NCT06738407 is a clinical study titled "Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections". The goal of this open-label, randomized trial is to assess the efficacy of doxycycline prophylaxis in reducing incidences of bacterial sexually transmitted infections (STIs) among adolescent and young adult females while also evaluating acceptability and antimicrobial resistance in order to inform p...
What is the current status of trial NCT06738407?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 760 participants. The study started on 2026-02-27. Estimated completion is 2028-06-15.
What interventions are being tested in trial NCT06738407?
The interventions under investigation include: Doxycycline hyclate delayed released 200 mg (DRUG), Doxycycline hyclate delayed released 200 mg weekly (DRUG), Per standard of care with quarterly STI testing/treatment and sexual health counseling (OTHER).
Who is sponsoring clinical trial NCT06738407?
This trial is sponsored by Westat, which has 13 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06738407's enrollment target sits among peer trials
760 106th of 2000 higher than 1,895 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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