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NCT06730425 · ClinicalTrials.gov registry record
Examining Stress Salivary Biomarkers in Pediatric Patients Undergoing Dental Procedures
A clinical trial, sponsored by Midwestern University.
- Completed
- Registry status
- 66
- Enrollment target
NCT06730425: Completed study, sponsored by Midwestern University.
NCT06730425 is a clinical trial that has completed, run by Midwestern University. The registered enrollment target is 66 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06730425 has completed, sponsored by Midwestern University.
- COMPLETED
- Registry status
- 66 participants
- Enrollment target
Study Summary
Pediatric patients are susceptible to show signs of fear. One of the scenarios that have always been a source of fear is undergoing a dental procedure. Fear of undergoing dental procedure has been addressed as "dental fear", which can lead to avoidance of receiving dental care and may result to a decline in proper oral hygiene. Fear stimulates multiple cerebral responses and can be often related to an increased stress level. Stress level fluctuations during dental procedures can be examined by blood and salivary biomarkers. Given accessibility and minimal invasiveness, the collection of saliva samples constitutes an easy and cost-effective diagnostic method to investigate a variety of oral and systemic conditions. Cortisol and alpha amylase are present within the saliva and their levels are supposedly influenced by stress. In contrast, salivary IgA is not known to be influenced by stress level and can be used in comparison as a non-stress salivary biomarker. Fear of dental appointments is a well-known cause of stress and activation of the sympathetic nervous system in adolescents undergoing dental procedure. However, the examination of stress and stress-related factors in young individuals attending their first dental appointment compared to young individuals who present for an orthodontic application is largely understudies. Therefore, the aims of the study are: 1) to measure stress salivary biomarkers in pediatric patients before undergoing dental and/or orthodontic procedures; 2) assess whether subjective stress to dental treatment (as measured by dental anxiety, stress, and dental fear) is associated with objective stress measurements (as measured by collection of stress salivary biomarkers).
Primary Outcome
Levels of dental fear (measured with 15-75 Children\'s Fear Survey Schedule-Dental Subscale, with values \>38 identifying dental fear), dental anxiety (measured with 8-40 Modified Child Dental Anxiety Scale, with values \>19 identifying anxiety) and self-perceived stress (measured with 1-40 Perceived Stress Scale, with values \>14 identifying stress) will be correlated with levels of salivary cortisol, alpha-amylase and IgA
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 66 participants |
| Start Date | 2024-09-09 |
| Est. Completion | 2025-05-30 |
What the finished NCT06730425 record still lists
NCT06730425 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 66 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT06730425 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06730425 about?
NCT06730425 is a clinical study titled "Examining Stress Salivary Biomarkers in Pediatric Patients Undergoing Dental Procedures". Pediatric patients are susceptible to show signs of fear. One of the scenarios that have always been a source of fear is undergoing a dental procedure. Fear of undergoing dental procedure has been addressed as "dental fear", which can lead to avoidance of receiving dental care and may result to a de...
What is the current status of trial NCT06730425?
This trial is currently completed. The enrollment target is 66 participants. The study started on 2024-09-09. Estimated completion is 2025-05-30.
Who is sponsoring clinical trial NCT06730425?
This trial is sponsored by Midwestern University, which has 15 total clinical trials registered on ClinicalTrials.gov.
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