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NCT06716749 · ClinicalTrials.gov registry record · Phase 2
Effectiveness of Adding Morphine to Intraosseous Vancomycin for Pain Control in Total Knee Arthroplasty
A Phase 2 study, sponsored by Carilion Clinic.
- Completed
- Registry status
- Phase 2
- Development phase
- 100
- Enrollment target
NCT06716749: Completed Phase 2 study, sponsored by Carilion Clinic.
NCT06716749 is a Phase 2 study that has completed, run by Carilion Clinic. The registered enrollment target is 100 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (25% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06716749, a Phase 2 study, has completed, sponsored by Carilion Clinic.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 100 participants
- Enrollment target
Study Summary
Study investigators propose to investigate if a bony injection of pain medication during a knee replacement will help pain levels following primary knee replacement surgery. To investigate this, 86 patients will be enrolled. Half of the patients will receive a bony injection of antibiotics with morphine (pain medication) while the other half will receive a bony injection of antibiotics with placebo (no pain medication). Following surgery, patient pain levels and pain medication consumption will be measured. The injection is intraosseous meaning in the bone. The needle pierces the bone and the medication is injected into the bone. The site of injection is on the anterior (front) of the upper portion of the tibia. The medications are Vancomycin (antibiotic) and Morphine (pain medication) which are mixed in separate syringes and then injected. Intraosseous vancomycin is standard of care while intraosseous vancomycin with morphine is also standard of care, depending on operating surgeon.
Primary Outcome
Pain scores on a scale of 0-10 with 0 meaning no pain and 10 being the worst pain possible
Interventions
- DRUG Vancomycin
- DRUG Morphine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2024-12-01 |
| Est. Completion | 2025-06-02 |
| Phase | Phase 2 |
What the finished NCT06716749 record still lists
NCT06716749 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (25% lower).
The record links to 0 conditions, and to 2 interventions - of which Vancomycin is the first listed.
NCT06716749 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06716749 about?
NCT06716749 is a clinical study titled "Effectiveness of Adding Morphine to Intraosseous Vancomycin for Pain Control in Total Knee Arthroplasty". Study investigators propose to investigate if a bony injection of pain medication during a knee replacement will help pain levels following primary knee replacement surgery. To investigate this, 86 patients will be enrolled. Half of the patients will receive a bony injection of antibiotics with morp...
What is the current status of trial NCT06716749?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 100 participants. The study started on 2024-12-01. Estimated completion is 2025-06-02.
What interventions are being tested in trial NCT06716749?
The interventions under investigation include: Vancomycin (DRUG), Morphine (DRUG).
Who is sponsoring clinical trial NCT06716749?
This trial is sponsored by Carilion Clinic, which has 45 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06716749's enrollment target sits among peer trials
100 672nd of 2000 higher than 1,263 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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