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Integrated Molecular and Clinical Profiling of Transformed Splenic Marginal Zone Lymphoma
NCT06712459 · View on ClinicalTrials.gov ↗
Study Summary
Histological transformation in Splenic Marginal Zone Lymphoma (t-SMZL) represents an unmet clinical and biological need, invariably associated with poor prognosis and reduced overall survival. At the present time, there are no recommended treatments intended specifically to t-SMZL and little is known about t-SMZL genetic complexity. The aim of this study is to provide information that will help clinicians to better understand the complexity of the disease. The information gained from this study will also lead to more specific and effective treatment for patients with t-SMZL.
Conditions Studied
Study Locations (7)
Other
- Universitz Hospitals Leuven — Leuven
- Hôpital Saint Louis — Paris
- Fondazione IRCCS Policlinico San Matteo — Pavia
- Hospital Clínic de Barcelona — Barcelona
- Oncology Institute of Southern Switzerland — Bellinzona
- University Hospitals Dorset — Bournemouth
New York
- Columbia University — New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2025-10-13 |
| Est. Completion | 2029-03 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06712459
The ClinicalTrials.gov registry entry for NCT06712459 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 100 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is International Extranodal Lymphoma Study Group (IELSG), which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Transformed Splenic Marginal Zone Lymphoma appearing as the primary indexed condition, and to 0 interventions. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06712459 reports 7 study locations spanning 2 distinct geographic areas — top geographies include Other, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06712459 about?
NCT06712459 is a clinical study titled "Integrated Molecular and Clinical Profiling of Transformed Splenic Marginal Zone Lymphoma". Histological transformation in Splenic Marginal Zone Lymphoma (t-SMZL) represents an unmet clinical and biological need, invariably associated with poor prognosis and reduced overall survival. At the present time, there are no recommended treatments intended specifically to t-SMZL and little is know...
What is the current status of trial NCT06712459?
This trial is currently recruiting. The enrollment target is 100 participants. The study started on 2025-10-13. Estimated completion is 2029-03.
What conditions does trial NCT06712459 study?
This clinical trial studies the following conditions: Transformed Splenic Marginal Zone Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
Who is sponsoring clinical trial NCT06712459?
This trial is sponsored by International Extranodal Lymphoma Study Group (IELSG), which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06712459 being conducted?
This trial has 7 study locations across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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