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NCT06705842 · ClinicalTrials.gov registry record · Phase 4
APPI-Cost Trial for Perforated Appendicitis
A Phase 4 study of Perforated Appendicitis, sponsored by The University of Texas Health Science Center, Houston.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 346
- Enrollment target
- 1
- Study location
NCT06705842: Recruiting Phase 4 study of Perforated Appendicitis, sponsored by The University of Texas Health Science Center, Houston.
NCT06705842 is a Phase 4 study of Perforated Appendicitis that is actively recruiting participants, run by The University of Texas Health Science Center, Houston. The registered enrollment target is 346 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (33% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06705842, a Phase 4 study of Perforated Appendicitis, is actively recruiting participants, sponsored by The University of Texas Health Science Center, Houston.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 346 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study to assess the clinical effectiveness and cost-effectiveness of povidone-iodine (PVI) irrigation in perforated appendicitis, to investigate barriers and facilitators to future implementation of PVI irrigation, and to collect costs and clinical and patient-reported outcomes among patients with non-perforated appendicitis.
Primary Outcome
Cost-effectiveness of PVI irrigation relative to usual care will be assessed as the incremental 30-day total societal costs per percent reduction in IAA rate. The Incremental Cost Effectiveness Ratio (ICER) will be calculated as: (societal costs with PVI irrigation minus societal costs with usual care) divided by (IAA rate with PVI minus IAA rate with usual care). IAA will be defined as an image-confirmed fluid collection deemed to be an IAA by an attending surgeon or radiologist, or an abscess
Conditions Studied
Interventions
- DRUG PVI
- DRUG Usual Care
Study Locations (1)
Texas
- The University of Texas Health Science Center at Houston - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 346 participants |
| Start Date | 2025-04-07 |
| Est. Completion | 2027-03-31 |
| Phase | Phase 4 |
What NCT06705842 shows while recruiting
NCT06705842 is an interventional study that assigns participants to a tested intervention. The registered 346 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (33% lower).
The record links to 1 condition, with Perforated Appendicitis appearing as the primary indexed condition, and to 2 interventions - of which PVI is the first listed.
NCT06705842 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT06705842 about?
NCT06705842 is a clinical study titled "APPI-Cost Trial for Perforated Appendicitis". The purpose of this study to assess the clinical effectiveness and cost-effectiveness of povidone-iodine (PVI) irrigation in perforated appendicitis, to investigate barriers and facilitators to future implementation of PVI irrigation, and to collect costs and clinical and patient-reported outcomes a...
What is the current status of trial NCT06705842?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 346 participants. The study started on 2025-04-07. Estimated completion is 2027-03-31.
What conditions does trial NCT06705842 study?
This clinical trial studies the following conditions: Perforated Appendicitis.
What interventions are being tested in trial NCT06705842?
The interventions under investigation include: PVI (DRUG), Usual Care (DRUG).
Who is sponsoring clinical trial NCT06705842?
This trial is sponsored by The University of Texas Health Science Center, Houston, which has 732 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06705842 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06705842's enrollment target sits among peer trials
346 242nd of 2000 higher than 1,758 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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