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NCT06677957 · ClinicalTrials.gov registry record · Phase 1
A Clinical Trial to Investigate the Clinical Drug-Drug Interaction of Divarasib With Probe Substrates of P-Glycoprotein and Breast Cancer Resistance Protein in Healthy Participants
A Phase 1 study, sponsored by Genentech.
- Completed
- Registry status
- Phase 1
- Development phase
- 19
- Enrollment target
NCT06677957 is a Phase 1 study that has completed, run by Genentech. The registered enrollment target is 19 participants.
The verdict
NCT06677957, a Phase 1 study, has completed, sponsored by Genentech.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 19 participants
- Enrollment target
Study Summary
This is a Phase 1, open-label, two-period, one-sequence, crossover drug-drug interaction study to assess the P-gp and BCRP inhibition potential of divarasib using digoxin and rosuvastatin as probe substrates, respectively, in healthy participants.
Interventions
- DRUG Divarasib
- DRUG Rosuvastatin
- DRUG Digoxin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 19 participants |
| Start Date | 2024-11-06 |
| Est. Completion | 2024-12-30 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06677957
The ClinicalTrials.gov registry entry for NCT06677957 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 19 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Genentech, which has 332 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which Divarasib is the first listed.
NCT06677957 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT06677957 about?
NCT06677957 is a clinical study titled "A Clinical Trial to Investigate the Clinical Drug-Drug Interaction of Divarasib With Probe Substrates of P-Glycoprotein and Breast Cancer Resistance Protein in Healthy Participants". This is a Phase 1, open-label, two-period, one-sequence, crossover drug-drug interaction study to assess the P-gp and BCRP inhibition potential of divarasib using digoxin and rosuvastatin as probe substrates, respectively, in healthy participants.
What is the current status of trial NCT06677957?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 19 participants. The study started on 2024-11-06. Estimated completion is 2024-12-30.
What interventions are being tested in trial NCT06677957?
The interventions under investigation include: Divarasib (DRUG), Rosuvastatin (DRUG), Digoxin (DRUG).
Who is sponsoring clinical trial NCT06677957?
This trial is sponsored by Genentech, which has 332 total clinical trials registered on ClinicalTrials.gov.
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