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NCT06677957 · ClinicalTrials.gov registry record · Phase 1
A Clinical Trial to Investigate the Clinical Drug-Drug Interaction of Divarasib With Probe Substrates of P-Glycoprotein and Breast Cancer Resistance Protein in Healthy Participants
A Phase 1 study, sponsored by Genentech.
- Completed
- Registry status
- Phase 1
- Development phase
- 19
- Enrollment target
NCT06677957: Completed Phase 1 study, sponsored by Genentech.
NCT06677957 is a Phase 1 study that has completed, run by Genentech. The registered enrollment target is 19 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (68% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06677957, a Phase 1 study, has completed, sponsored by Genentech.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 19 participants
- Enrollment target
Study Summary
This is a Phase 1, open-label, two-period, one-sequence, crossover drug-drug interaction study to assess the P-gp and BCRP inhibition potential of divarasib using digoxin and rosuvastatin as probe substrates, respectively, in healthy participants.
Interventions
- DRUG Divarasib
- DRUG Rosuvastatin
- DRUG Digoxin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 19 participants |
| Start Date | 2024-11-06 |
| Est. Completion | 2024-12-30 |
| Phase | Phase 1 |
What the finished NCT06677957 record still lists
NCT06677957 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 19 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (68% lower).
The record links to 0 conditions, and to 3 interventions - of which Divarasib is the first listed.
NCT06677957 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06677957 about?
NCT06677957 is a clinical study titled "A Clinical Trial to Investigate the Clinical Drug-Drug Interaction of Divarasib With Probe Substrates of P-Glycoprotein and Breast Cancer Resistance Protein in Healthy Participants". This is a Phase 1, open-label, two-period, one-sequence, crossover drug-drug interaction study to assess the P-gp and BCRP inhibition potential of divarasib using digoxin and rosuvastatin as probe substrates, respectively, in healthy participants.
What is the current status of trial NCT06677957?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 19 participants. The study started on 2024-11-06. Estimated completion is 2024-12-30.
What interventions are being tested in trial NCT06677957?
The interventions under investigation include: Divarasib (DRUG), Rosuvastatin (DRUG), Digoxin (DRUG).
Who is sponsoring clinical trial NCT06677957?
This trial is sponsored by Genentech, which has 332 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06677957's enrollment target sits among peer trials
19 1716th of 2000 higher than 281 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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