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NCT06658847 · ClinicalTrials.gov registry record · NA
A Study to Evaluate the Effect of a Topical Retinol on Epigenetic Changes and Expression of Certain Genes in the Skin Using Non-invasive Measurements
A NA study, sponsored by Johnson & Johnson Consumer Inc. (J&JCI).
- Completed
- Registry status
- NA
- Development phase
- 66
- Enrollment target
NCT06658847: Completed NA study, sponsored by Johnson & Johnson Consumer Inc. (J&JCI).
NCT06658847 is a NA study that has completed, run by Johnson & Johnson Consumer Inc. (J&JCI). The registered enrollment target is 66 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06658847, a NA study, has completed, sponsored by Johnson & Johnson Consumer Inc. (J&JCI).
- COMPLETED
- Registry status
- NA
- Development phase
- 66 participants
- Enrollment target
Study Summary
This study is being conducted to confirm whether skin tape stripping methodology can identify changes in gene expression (i.e. whether different genes are turned on to make proteins) in aged skin after use of a retinoid.
Primary Outcome
The investigator will collect skin samples from subjects through a non-invasive method - tape stripping. The tape strips will be analyzed by extracting DNA collected from the epidermal skin cells then use targeted sequencing using 4M CpG sites to further analyze if certain genes (assessment of UV damage, smoking, and biological age ) are turned on or off from retinol use. Baseline samples will be compared to Day 71 samples.
Interventions
- OTHER Night Cream Usage
- OTHER No Night Cream Usage
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 66 participants |
| Start Date | 2024-11-07 |
| Est. Completion | 2025-04-29 |
| Phase | NA |
What the finished NCT06658847 record still lists
NCT06658847 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 66 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 2 interventions - of which Night Cream Usage is the first listed.
NCT06658847 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06658847 about?
NCT06658847 is a clinical study titled "A Study to Evaluate the Effect of a Topical Retinol on Epigenetic Changes and Expression of Certain Genes in the Skin Using Non-invasive Measurements". This study is being conducted to confirm whether skin tape stripping methodology can identify changes in gene expression (i.e. whether different genes are turned on to make proteins) in aged skin after use of a retinoid.
What is the current status of trial NCT06658847?
This trial is currently completed. It is a NA study. The enrollment target is 66 participants. The study started on 2024-11-07. Estimated completion is 2025-04-29.
What interventions are being tested in trial NCT06658847?
The interventions under investigation include: Night Cream Usage (OTHER), No Night Cream Usage (OTHER).
Who is sponsoring clinical trial NCT06658847?
This trial is sponsored by Johnson & Johnson Consumer Inc. (J&JCI), which has 40 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06658847's enrollment target sits among peer trials
66 1139th of 2000 higher than 857 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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