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NCT06654557 · ClinicalTrials.gov registry record · NA
Effect of Adding Glycerol to Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at Rest
A NA study of Fluid Balance, sponsored by PepsiCo Global R&D.
- Recruiting
- Registry status
- NA
- Development phase
- 95
- Enrollment target
- 1
- Study location
NCT06654557: Recruiting NA study of Fluid Balance, sponsored by PepsiCo Global R&D.
NCT06654557 is a NA study of Fluid Balance that is actively recruiting participants, run by PepsiCo Global R&D. The registered enrollment target is 95 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06654557, a NA study of Fluid Balance, is actively recruiting participants, sponsored by PepsiCo Global R&D.
- RECRUITING
- Registry status
- NA
- Development phase
- 95 participants
- Enrollment target
- 1
- Study location
Study Summary
The results of a prior study PEP-2311 suggested there was a positive dose-response effect of glycerol and sodium on fluid balance and fluid retention. In addition, inclusion of glycerol resulted in an upward shift in the relationship between sodium concentration and fluid balance. The practical interpretation is that addition of glycerol enables a reduction in sodium concentration compared with a 0% glycerol drink. In this follow-up study, the investigators hypothesize that 1) fluid balance will be sustained (greater than or not different from baseline) and significantly greater than placebo for 120 min after drinking the test no/low/moderate carbohydrate beverages and 2) fluid balance will not differ between the carbohydrate-electrolyte beverages, but both will be greater than placebo.
Primary Outcome
Platform scale to the nearest 0.005 kilograms (kg)
Conditions Studied
Interventions
- OTHER Placebo beverage, kiwi-strawberry flavor (Part 1 and Part 2)
- OTHER 0% carbohydrate electrolyte solution with glycerol beverage (Part 1 only)
- OTHER 0% carbohydrate electrolyte solution without glycerol beverage (Part 1 only)
- OTHER 1% carbohydrate electrolyte solution with glycerol beverage (Parts 1 and 2)
- OTHER 6% carbohydrate electrolyte solution with glycerol beverage (Parts 1 and 2)
Study Locations (1)
New York
- PepsiCo R&D, Gatorade Sports Science Institute - Valhalla
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 95 participants |
| Start Date | 2024-09-30 |
| Est. Completion | 2025-05-30 |
| Phase | NA |
What NCT06654557 shows while recruiting
NCT06654557 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 95 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower).
The record links to 1 condition, with Fluid Balance appearing as the primary indexed condition, and to 5 interventions - of which Placebo beverage, kiwi-strawberry flavor (Part 1 and Part 2) is the first listed.
NCT06654557 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT06654557 about?
NCT06654557 is a clinical study titled "Effect of Adding Glycerol to Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at Rest". The results of a prior study PEP-2311 suggested there was a positive dose-response effect of glycerol and sodium on fluid balance and fluid retention. In addition, inclusion of glycerol resulted in an upward shift in the relationship between sodium concentration and fluid balance. The practical inte...
What is the current status of trial NCT06654557?
This trial is currently recruiting. It is a NA study. The enrollment target is 95 participants. The study started on 2024-09-30. Estimated completion is 2025-05-30.
What conditions does trial NCT06654557 study?
This clinical trial studies the following conditions: Fluid Balance.
What interventions are being tested in trial NCT06654557?
The interventions under investigation include: Placebo beverage, kiwi-strawberry flavor (Part 1 and Part 2) (OTHER), 0% carbohydrate electrolyte solution with glycerol beverage (Part 1 only) (OTHER), 0% carbohydrate electrolyte solution without glycerol beverage (Part 1 only) (OTHER), 1% carbohydrate electrolyte solution with glycerol beverage (Parts 1 and 2) (OTHER), 6% carbohydrate electrolyte solution with glycerol beverage (Parts 1 and 2) (OTHER).
Who is sponsoring clinical trial NCT06654557?
This trial is sponsored by PepsiCo Global R&D, which has 47 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06654557 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06654557's enrollment target sits among peer trials
95 931st of 2000 higher than 1,066 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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