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NCT06648460 · ClinicalTrials.gov registry record · NA
Multimodal Differences in Effort-based Decision-Making in Depression
A NA study, sponsored by Georgia Institute of Technology.
- Not yet
- Registry status
- NA
- Development phase
- 90
- Enrollment target
NCT06648460: Clinical Trial NA study, sponsored by Georgia Institute of Technology.
NCT06648460 is a NA study that has not yet begun recruiting, run by Georgia Institute of Technology. The registered enrollment target is 90 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06648460, a NA study, has not yet begun recruiting, sponsored by Georgia Institute of Technology.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 90 participants
- Enrollment target
Study Summary
Major depressive disorder (MDD) is a serious condition that causes long-term symptoms such as feeling sad, losing interest in activities, and having thoughts of self-harm. Difficulty in making an effort is a key factor in functional impairment. Current methods to evaluate this difficulty use clinical assessments and computer-based tasks, but there is a gap between the measurements and real-life behavior. To address this, the study team proposes creating an instrumented behavioral test, HORMES, to objectively assess reduced motivation during everyday activities and measure physiological responses. The study will examine differences in brain activity, autonomic system function, and metabolic energy expenditure in patients with major depression during a decision-making task that involves physical effort.
Primary Outcome
Participants will be measured on how much time they spend in "rooms" that require high effort in the form of walking on an inclined treadmill as a proportion of the total duration of the task. This measures the willingness of participants to engage in effortful behavior.
Interventions
- OTHER Effort-based Decision-Making Task
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2026-08-01 |
| Est. Completion | 2030-09-30 |
| Phase | NA |
What is known before NCT06648460 opens enrollment
NCT06648460 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 90 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower).
The record links to 0 conditions, and to 1 intervention - of which Effort-based Decision-Making Task is the first listed.
NCT06648460 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06648460 about?
NCT06648460 is a clinical study titled "Multimodal Differences in Effort-based Decision-Making in Depression". Major depressive disorder (MDD) is a serious condition that causes long-term symptoms such as feeling sad, losing interest in activities, and having thoughts of self-harm. Difficulty in making an effort is a key factor in functional impairment. Current methods to evaluate this difficulty use clinica...
What is the current status of trial NCT06648460?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 90 participants. The study started on 2026-08-01. Estimated completion is 2030-09-30.
What interventions are being tested in trial NCT06648460?
The interventions under investigation include: Effort-based Decision-Making Task (OTHER).
Who is sponsoring clinical trial NCT06648460?
This trial is sponsored by Georgia Institute of Technology, which has 24 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06648460's enrollment target sits among peer trials
90 941st of 2000 higher than 1,029 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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