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NCT06634420 · ClinicalTrials.gov registry record · Phase 3
HAELO: A Phase 3 Study to Evaluate NTLA-2002 in Participants With Hereditary Angioedema (HAE)
A Phase 3 study of Hereditary Angioedema, sponsored by Intellia Therapeutics.
- Active
- Registry status
- Phase 3
- Development phase
- 60
- Enrollment target
- 20
- Study locations
NCT06634420: Active Phase 3 study of Hereditary Angioedema, sponsored by Intellia Therapeutics.
NCT06634420 is a Phase 3 study of Hereditary Angioedema that is active but no longer recruiting, run by Intellia Therapeutics. The registered enrollment target is 60 participants, below the 72-participant average among 14 other Hereditary Angioedema trials with a reported enrollment target (17% lower). The trial reports 20 study locations across 15 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06634420, a Phase 3 study of Hereditary Angioedema, is active but no longer recruiting, sponsored by Intellia Therapeutics.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 3
- Development phase
- 60 participants
- Enrollment target
- 20
- Study locations
Study Summary
This Phase 3 study aims to evaluate the efficacy and safety of NTLA-2002 compared to placebo in participants with HAE.
Conditions Studied
Interventions
- BIOLOGICAL NTLA-2002
- BIOLOGICAL Normal Saline IV Administration
Study Locations (20)
California
- University of California, San Diego (UCSD) - San Diego
- Raffi Tachdjian MD, Inc - Santa Monica
- Allergy & Asthma Clinical Research - Walnut Creek
Colorado
- IMMUNOe International Research Centers - Centennial
- Asthma & Allergy Associates - Colorado Springs
New York
- NYU Langone Health - Long Island - Mineola
- Icahn School of Medicine at Mount Sinai - New York
Victoria
- The Alfred Hospital - Melbourne
- Royal Melbourne Hospital - Parkville
Arizona
- Medical Research of Arizona - Scottsdale
Florida
- University of South Florida - Tampa
Massachusetts
- Massachusetts General Hospital - Boston
Missouri
- Washington University in St. Louis - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2025-01-15 |
| Est. Completion | 2027-09 |
| Phase | Phase 3 |
What the registry record for NCT06634420 still lists
NCT06634420 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 72-participant average among 14 other Hereditary Angioedema trials with a reported enrollment target (17% lower).
The record links to 1 condition, with Hereditary Angioedema appearing as the primary indexed condition, and to 2 interventions - of which NTLA-2002 is the first listed.
NCT06634420 names 20 study sites across 15 states, led by California, Colorado, New York.
Frequently Asked Questions
What is clinical trial NCT06634420 about?
NCT06634420 is a clinical study titled "HAELO: A Phase 3 Study to Evaluate NTLA-2002 in Participants With Hereditary Angioedema (HAE)". This Phase 3 study aims to evaluate the efficacy and safety of NTLA-2002 compared to placebo in participants with HAE.
What is the current status of trial NCT06634420?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 60 participants. The study started on 2025-01-15. Estimated completion is 2027-09.
What conditions does trial NCT06634420 study?
This clinical trial studies the following conditions: Hereditary Angioedema.
What interventions are being tested in trial NCT06634420?
The interventions under investigation include: NTLA-2002 (BIOLOGICAL), Normal Saline IV Administration (BIOLOGICAL).
Who is sponsoring clinical trial NCT06634420?
This trial is sponsored by Intellia Therapeutics, which has 3 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06634420 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Florida, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hereditary Angioedema
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06634420's enrollment target sits among peer trials
60 8th of 14 higher than 7 of 14 other Hereditary Angioedema trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hereditary Angioedema trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
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