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ACTIVE NOT RECRUITING Phase 3

HAELO: A Phase 3 Study to Evaluate NTLA-2002 in Participants With Hereditary Angioedema (HAE)

NCT06634420 · View on ClinicalTrials.gov ↗

Study Summary

This Phase 3 study aims to evaluate the efficacy and safety of NTLA-2002 compared to placebo in participants with HAE.

Conditions Studied

Interventions

  • BIOLOGICAL NTLA-2002
  • BIOLOGICAL Normal Saline IV Administration

Study Locations (20)

California

  • University of California, San Diego (UCSD) — San Diego
  • Raffi Tachdjian MD, Inc — Santa Monica
  • Allergy & Asthma Clinical Research — Walnut Creek

Colorado

  • IMMUNOe International Research Centers — Centennial
  • Asthma & Allergy Associates — Colorado Springs

New York

  • NYU Langone Health - Long Island — Mineola
  • Icahn School of Medicine at Mount Sinai — New York

Victoria

  • The Alfred Hospital — Melbourne
  • Royal Melbourne Hospital — Parkville

Arizona

  • Medical Research of Arizona — Scottsdale

Florida

  • University of South Florida — Tampa

Massachusetts

  • Massachusetts General Hospital — Boston

Missouri

  • Washington University in St. Louis — St Louis

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2025-01-15
Est. Completion 2027-09
Phase Phase 3

Sponsor

Intellia Therapeutics

2 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06634420

The ClinicalTrials.gov registry entry for NCT06634420 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Intellia Therapeutics, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Hereditary Angioedema appearing as the primary indexed condition, and to 2 interventions — of which NTLA-2002 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06634420 reports 20 study locations spanning 15 distinct geographic areas — top geographies include California, Colorado, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06634420 about?

NCT06634420 is a clinical study titled "HAELO: A Phase 3 Study to Evaluate NTLA-2002 in Participants With Hereditary Angioedema (HAE)". This Phase 3 study aims to evaluate the efficacy and safety of NTLA-2002 compared to placebo in participants with HAE.

What is the current status of trial NCT06634420?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 60 participants. The study started on 2025-01-15. Estimated completion is 2027-09.

What conditions does trial NCT06634420 study?

This clinical trial studies the following conditions: Hereditary Angioedema. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06634420?

The interventions under investigation include: NTLA-2002 (BIOLOGICAL), Normal Saline IV Administration (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06634420?

This trial is sponsored by Intellia Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06634420 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Florida, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial