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NCT06593600 · ClinicalTrials.gov registry record · Phase 2
Study of Natriuretic Peptide Receptor 1 (NPR1) Antagonist in Adult Patients With Postural Orthostatic Tachycardia Syndrome (POTS)
A Phase 2 study of Postural Orthostatic Tachycardia Syndrome (POTS), sponsored by Regeneron Pharmaceuticals.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 81
- Enrollment target
- 18
- Study locations
NCT06593600: Recruiting Phase 2 study of Postural Orthostatic Tachycardia Syndrome (POTS), sponsored by Regeneron Pharmaceuticals.
NCT06593600 is a Phase 2 study of Postural Orthostatic Tachycardia Syndrome (POTS) that is actively recruiting participants, run by Regeneron Pharmaceuticals. The registered enrollment target is 81 participants, below the 90-participant average among 4 other Postural Orthostatic Tachycardia Syndrome (POTS) trials with a reported enrollment target (10% lower). The trial reports 18 study locations across 14 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06593600, a Phase 2 study of Postural Orthostatic Tachycardia Syndrome (POTS), is actively recruiting participants, sponsored by Regeneron Pharmaceuticals.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 81 participants
- Enrollment target
- 18
- Study locations
Study Summary
This study is researching an experimental drug called REGN7544 (called "study drug"). The study is focused on participants with POTS. The aim of the study is to see how safe, tolerable, and effective the study drug is. The study is looking at several other research questions, including: * How the study drug changes heart rate and blood pressure in participants with POTS * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects)
Conditions Studied
Interventions
- DRUG Placebo
- DRUG REGN7544
Study Locations (18)
California
- North County Neurology Associates - Carlsbad
- Stanford University - Palo Alto
- Southern California Heart Specialists - Pasadena
New York
- New York University Langone - New York
- Columbia University - New York
Alberta
- University of Calgary - Calgary
- University of Alberta Hospital - Edmonton
Arizona
- Mercy Gilbert Medical Center - Gilbert
Connecticut
- Yale University - New Haven
Florida
- Innovative Research of West Florida, Inc. - Clearwater
Indiana
- Indiana University Health Neuroscience Center - Indianapolis
Massachusetts
- Beth Israel Deaconess Medical Center - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 81 participants |
| Start Date | 2024-11-13 |
| Est. Completion | 2026-06-11 |
| Phase | Phase 2 |
What NCT06593600 shows while recruiting
NCT06593600 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 81 participants, a relatively small participant target, below the 90-participant average among 4 other Postural Orthostatic Tachycardia Syndrome (POTS) trials with a reported enrollment target (10% lower).
The record links to 1 condition, with Postural Orthostatic Tachycardia Syndrome (POTS) appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06593600 lists 18 locations in 14 states (California, New York, Alberta).
Frequently Asked Questions
What is clinical trial NCT06593600 about?
NCT06593600 is a clinical study titled "Study of Natriuretic Peptide Receptor 1 (NPR1) Antagonist in Adult Patients With Postural Orthostatic Tachycardia Syndrome (POTS)". This study is researching an experimental drug called REGN7544 (called "study drug"). The study is focused on participants with POTS. The aim of the study is to see how safe, tolerable, and effective the study drug is. The study is looking at several other research questions, including: * How the...
What is the current status of trial NCT06593600?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 81 participants. The study started on 2024-11-13. Estimated completion is 2026-06-11.
What conditions does trial NCT06593600 study?
This clinical trial studies the following conditions: Postural Orthostatic Tachycardia Syndrome (POTS).
What interventions are being tested in trial NCT06593600?
The interventions under investigation include: Placebo (DRUG), REGN7544 (DRUG).
Who is sponsoring clinical trial NCT06593600?
This trial is sponsored by Regeneron Pharmaceuticals, which has 280 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06593600 being conducted?
This trial has 18 study locations across Arizona, California, Connecticut, Florida, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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