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RECRUITING Phase 2

Beamion PANTUMOR-1: A Study to Test Whether Zongertinib Helps People With Advanced Cancers With HER2 Alterations

NCT06581432 · View on ClinicalTrials.gov ↗

Study Summary

This is a study for people with advanced cancer for whom previous treatment was not successful. Adults aged 18 and over with advanced cancer with HER2 alterations can join the study. The purpose of this study is to find out whether a medicine called zongertinib helps people with advanced cancers with HER2 alterations. HER2 alterations can cause cancer. Zongertinib inhibits HER2. Participants are put into 13 groups based on the type of advanced cancer and the type of HER2 alterations they have. All participants take one dose of zongertinib each day. Participants can continue the treatment as long as they benefit from it and can tolerate it. Participants visit the study site regularly. During many of the visits, the doctors check the size of the tumour and whether it has spread to other parts of the body. During all the visits, the doctors check participants' health and take note of any unwanted effects.

Conditions Studied

Interventions

  • DRUG Zongertinib

Study Locations (20)

California

  • Precision NextGen Oncology — Beverly Hills
  • Scripps Cancer Center Torrey Pines — La Jolla
  • Valkyrie Clinical Trials — Los Angeles

New York

  • Icahn School of Medicine at Mount Sinai — New York
  • Memorial Sloan-Kettering Cancer Center — New York

Texas

  • Sarah Cannon Research Institute at Mary Crowley — Dallas
  • The University of Texas MD Anderson Cancer Center — Houston

New South Wales

  • Macquarie University — Macquarie Park
  • GenesisCare North Shore — St Leonards

Alaska

  • Alaska Oncology and Hematology, LLC — Anchorage

Arizona

  • University of Arizona Comprehensive Cancer Center — Tucson

Connecticut

  • Yale University School of Medicine — New Haven

Florida

  • BRCR Global — Tamarac

Trial Details

FieldValue
Enrollment Target 430 participants
Start Date 2024-10-11
Est. Completion 2028-12-29
Phase Phase 2

Sponsor

Boehringer Ingelheim

203 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06581432

The ClinicalTrials.gov registry entry for NCT06581432 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 430 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Boehringer Ingelheim, which has 203 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Solid Tumours appearing as the primary indexed condition, and to 1 intervention — of which Zongertinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06581432 reports 20 study locations spanning 15 distinct geographic areas — top geographies include California, New York, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06581432 about?

NCT06581432 is a clinical study titled "Beamion PANTUMOR-1: A Study to Test Whether Zongertinib Helps People With Advanced Cancers With HER2 Alterations". This is a study for people with advanced cancer for whom previous treatment was not successful. Adults aged 18 and over with advanced cancer with HER2 alterations can join the study. The purpose of this study is to find out whether a medicine called zongertinib helps people with advanced cancers wit...

What is the current status of trial NCT06581432?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 430 participants. The study started on 2024-10-11. Estimated completion is 2028-12-29.

What conditions does trial NCT06581432 study?

This clinical trial studies the following conditions: Solid Tumours. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06581432?

The interventions under investigation include: Zongertinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06581432?

This trial is sponsored by Boehringer Ingelheim, which has 203 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06581432 being conducted?

This trial has 20 study locations across Alaska, Arizona, California, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial