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NCT06578728 · ClinicalTrials.gov registry record · Phase 4
Local Methotrexate Injections for the Treatment of Nail Psoriasis
A Phase 4 study, sponsored by Weill Medical College of Cornell University.
- Terminated
- Registry status
- Phase 4
- Development phase
- 1
- Enrollment target
NCT06578728: Clinical Trial Phase 4 study, sponsored by Weill Medical College of Cornell University.
NCT06578728 is a Phase 4 study that was terminated before completion, run by Weill Medical College of Cornell University. The registered enrollment target is 1 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06578728, a Phase 4 study, was terminated before completion, sponsored by Weill Medical College of Cornell University.
- TERMINATED
- Registry status
- Phase 4
- Development phase
- 1 participants
- Enrollment target
Study Summary
The investigators hope to learn the efficacy of methotrexate injections for treatment of nail psoriasis.
Primary Outcome
Mean change from baseline of the Nail Psoriasis Severity Index, which evaluates nail psoriasis symptoms with a score of 0-8 for each nail. Scores will be collected and analyzed per nail. For each nail measured by the study, patients can have a score between 0 and 8. A score of 0 indicates no symptoms of nail psoriasis in the nail, and a score of 8 indicates nail psoriasis features are present in four quadrants of both the nail bed and nail matrix.
Interventions
- DRUG Saline
- DRUG Methotrexate
- DRUG Triamcinolone Acetonide 10mg/mL
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1 participants |
| Start Date | 2025-09-10 |
| Est. Completion | 2026-06-05 |
| Phase | Phase 4 |
Why NCT06578728 stopped before completion
NCT06578728 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 1 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 3 interventions - of which Saline is the first listed.
NCT06578728 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06578728 about?
NCT06578728 is a clinical study titled "Local Methotrexate Injections for the Treatment of Nail Psoriasis". The investigators hope to learn the efficacy of methotrexate injections for treatment of nail psoriasis.
What is the current status of trial NCT06578728?
This trial is currently terminated. It is a Phase 4 study. The enrollment target is 1 participants. The study started on 2025-09-10. Estimated completion is 2026-06-05.
What interventions are being tested in trial NCT06578728?
The interventions under investigation include: Saline (DRUG), Methotrexate (DRUG), Triamcinolone Acetonide 10mg/mL (DRUG).
Who is sponsoring clinical trial NCT06578728?
This trial is sponsored by Weill Medical College of Cornell University, which has 701 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06578728's enrollment target sits among peer trials
1 2000th of 2000 the lowest of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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