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RECRUITING Phase 3

A Study to Learn About the Investigational Medicine Called PF-06821497 (Mevrometostat) in Men With mCRPC Who Were Previously Treated With Abiraterone Acetate for Prostate Cancer (MEVPRO-1).

NCT06551324 · View on ClinicalTrials.gov ↗

Study Summary

Pfizer MEVPRO-1 (C2321014) is a randomized, open-label, multi-center clinical trial evaluating whether combining the study medicine (PF-06821497) with enzalutamide is safe and effective compared to physician's choice of either second-line androgen receptor (AR) directed therapy with enzalutamide or docetaxel (chemotherapy) for treating metastatic castration-resistant prostate cancer (mCRPC) after progression on prior abiraterone acetate treatment. The primary objective of this clinical trial is to assess the radiographic progression free survival (rPFS) of the combination of PF-06821497 plus enzalutamide versus physician's choice of enzalutamide or docetaxel.

Interventions

  • DRUG Docetaxel
  • DRUG Enzalutamide
  • DRUG PF-06821497

Study Locations (20)

California

  • Los Angeles Cancer Network — Anaheim
  • UCSF Cancer Center Berkeley — Berkeley
  • UCSF Cancer Center Burlingame — Burlingame
  • Los Angeles Cancer Network — Fountain Valley
  • Los Angeles Cancer Network — Glendale
  • Los Angeles Cancer Network — Glendale
  • Los Angeles Cancer Network — Los Angeles
  • Los Angeles Cancer Network — Los Angeles
  • Stanford Cancer Center — Palo Alto
  • UCSF Investigational Drug Pharmacy — San Francisco
  • UCSF Medical Center at Mission Bay — San Francisco
  • UCSF Cancer Center San Mateo — San Mateo

Arizona

  • Ironwood Cancer & Research Centers — Chandler
  • Ironwood Cancer & Research Centers — Gilbert
  • Ironwood Cancer & Research Centers — Glendale
  • Ironwood Cancer & Research Centers — Mesa
  • Ironwood Cancer & Research Centers — Mesa
  • Ironwood Cancer & Research Centers — Phoenix
  • Ironwood Cancer & Research Centers — Scottsdale

Alabama

  • Urology Centers of Alabama — Homewood

Trial Details

FieldValue
Enrollment Target 600 participants
Start Date 2024-10-21
Est. Completion 2028-10-29
Phase Phase 3

Sponsor

Pfizer

769 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06551324

The ClinicalTrials.gov registry entry for NCT06551324 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 600 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pfizer, which has 769 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Metastatic Castrate Resistant Prostate Cancer (mCRPC) appearing as the primary indexed condition, and to 3 interventions — of which Docetaxel is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06551324 reports 20 study locations spanning 3 distinct geographic areas — top geographies include California, Arizona, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06551324 about?

NCT06551324 is a clinical study titled "A Study to Learn About the Investigational Medicine Called PF-06821497 (Mevrometostat) in Men With mCRPC Who Were Previously Treated With Abiraterone Acetate for Prostate Cancer (MEVPRO-1).". Pfizer MEVPRO-1 (C2321014) is a randomized, open-label, multi-center clinical trial evaluating whether combining the study medicine (PF-06821497) with enzalutamide is safe and effective compared to physician's choice of either second-line androgen receptor (AR) directed therapy with enzalutamide or ...

What is the current status of trial NCT06551324?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 600 participants. The study started on 2024-10-21. Estimated completion is 2028-10-29.

What conditions does trial NCT06551324 study?

This clinical trial studies the following conditions: Metastatic Castrate Resistant Prostate Cancer (mCRPC). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06551324?

The interventions under investigation include: Docetaxel (DRUG), Enzalutamide (DRUG), PF-06821497 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06551324?

This trial is sponsored by Pfizer, which has 769 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06551324 being conducted?

This trial has 20 study locations across Alabama, Arizona, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial