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NCT06543576 · ClinicalTrials.gov registry record · Phase 1
External Beam Radiation Therapy and Brachytherapy With Chemotherapy and Immunotherapy for the Treatment of Stage IVB Cervical Cancer
A Phase 1 study of Cervical Squamous Cell Carcinoma and Cervical Adenocarcinoma, sponsored by Jonsson Comprehensive Cancer Center.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 35
- Enrollment target
- 4
- Study locations
NCT06543576: Recruiting Phase 1 study of Cervical Squamous Cell Carcinoma and Cervical Adenocarcinoma, sponsored by Jonsson Comprehensive Cancer Center.
NCT06543576 is a Phase 1 study of Cervical Squamous Cell Carcinoma and Cervical Adenocarcinoma that is actively recruiting participants, run by Jonsson Comprehensive Cancer Center. The registered enrollment target is 35 participants, below the 120-participant average among 13 other Cervical Squamous Cell Carcinoma trials with a reported enrollment target (71% lower). The trial reports 4 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06543576, a Phase 1 study of Cervical Squamous Cell Carcinoma and Cervical Adenocarcinoma, is actively recruiting participants, sponsored by Jonsson Comprehensive Cancer Center.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 35 participants
- Enrollment target
- 4
- Study locations
Study Summary
This phase I/II trial tests the safety and effectiveness of receiving external beam radiation therapy (EBRT) and brachytherapy along with chemotherapy, consisting of cisplatin and paclitaxel, and immunotherapy, consisting of bevacizumab and pembrolizumab, for the treatment of patients with stage IVB cervical cancer. EBRT is type of radiation therapy that uses a machine to aim high-energy rays at the cancer from outside of the body. Brachytherapy, also known as internal radiation therapy, uses radioactive material placed directly into or near a tumor to kill tumor cells. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of tumor cells. Paclitaxel is in a class of medications called antimicrotubule agents. It stops tumor cells from growing and dividing and may kill them. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. A monoclonal antibody, such as pembrolizumab, is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Giving EBRT and brachytherapy along with chemotherapy and immunotherapy may be a safe and effective way to treat patients with stage IVB cervical cancer.
Primary Outcome
Will be described using Kaplan-Meier plots and median estimates.
Conditions Studied
Interventions
- PROCEDURE Biospecimen Collection
- DRUG Cisplatin
- RADIATION External Beam Radiation Therapy
- RADIATION Brachytherapy
- BIOLOGICAL Bevacizumab
Study Locations (4)
California
- UCLA / Jonsson Comprehensive Cancer Center - Los Angeles
- University of California San Diego (UCSD) - San Diego
Oklahoma
- University of Oklahoma Health Sciences Center - Oklahoma City
Virginia
- University of Virginia Cancer Center - Charlottesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 35 participants |
| Start Date | 2025-07-29 |
| Est. Completion | 2032-01-31 |
| Phase | Phase 1 |
What NCT06543576 shows while recruiting
NCT06543576 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 35 participants, a relatively small participant target, below the 120-participant average among 13 other Cervical Squamous Cell Carcinoma trials with a reported enrollment target (71% lower).
The record links to 4 conditions, with Cervical Squamous Cell Carcinoma appearing as the primary indexed condition, and to 5 interventions - of which Biospecimen Collection is the first listed.
NCT06543576 reports a single indexed study location in California, Oklahoma, Virginia.
Frequently Asked Questions
What is clinical trial NCT06543576 about?
NCT06543576 is a clinical study titled "External Beam Radiation Therapy and Brachytherapy With Chemotherapy and Immunotherapy for the Treatment of Stage IVB Cervical Cancer". This phase I/II trial tests the safety and effectiveness of receiving external beam radiation therapy (EBRT) and brachytherapy along with chemotherapy, consisting of cisplatin and paclitaxel, and immunotherapy, consisting of bevacizumab and pembrolizumab, for the treatment of patients with stage IVB...
What is the current status of trial NCT06543576?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 35 participants. The study started on 2025-07-29. Estimated completion is 2032-01-31.
What conditions does trial NCT06543576 study?
This clinical trial studies the following conditions: Cervical Squamous Cell Carcinoma, Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Stage IVB Cervical Cancer American Joint Committee on Cancer (AJCC) v8.
What interventions are being tested in trial NCT06543576?
The interventions under investigation include: Biospecimen Collection (PROCEDURE), Cisplatin (DRUG), External Beam Radiation Therapy (RADIATION), Brachytherapy (RADIATION), Bevacizumab (BIOLOGICAL).
Who is sponsoring clinical trial NCT06543576?
This trial is sponsored by Jonsson Comprehensive Cancer Center, which has 321 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06543576 being conducted?
This trial has 4 study locations across California, Oklahoma, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cervical Squamous Cell Carcinoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06543576's enrollment target sits among peer trials
35 11th of 13 higher than 2 of 13 other Cervical Squamous Cell Carcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cervical Squamous Cell Carcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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