Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 1

Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer

NCT00104910 · View on ClinicalTrials.gov ↗

Study Summary

This phase I trial is studying the side effects and best dose of cetuximab when given together with cisplatin and radiation therapy in treating patients with stage IB, stage II, stage III, or stage IVA cervical cancer. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells. Internal radiation therapy uses radioactive material placed directly into or near a tumor to kill tumor cells. Giving cetuximab together with cisplatin and radiation therapy may kill more tumor cells.

Interventions

  • DRUG Cisplatin
  • BIOLOGICAL Cetuximab
  • RADIATION 3-Dimensional Conformal Radiation Therapy
  • RADIATION Internal Radiation Therapy

Study Locations (15)

Ohio

  • MetroHealth Medical Center — Cleveland
  • Cleveland Clinic Foundation — Cleveland
  • Riverside Methodist Hospital — Columbus
  • Lake University Ireland Cancer Center — Mentor

Texas

  • Parkland Memorial Hospital — Dallas
  • University of Texas Southwestern Medical Center — Dallas
  • M D Anderson Cancer Center — Houston

Georgia

  • Georgia Regents University Medical Center — Augusta

Illinois

  • University of Chicago Comprehensive Cancer Center — Chicago

Indiana

  • Indiana University/Melvin and Bren Simon Cancer Center — Indianapolis

Iowa

  • University of Iowa Hospitals and Clinics — Iowa City

Maryland

  • Johns Hopkins University/Sidney Kimmel Comprehensive Cancer Center — Baltimore

New Jersey

  • Cooper Hospital University Medical Center — Camden

Trial Details

FieldValue
Enrollment Target 64 participants
Start Date 2005-01
Phase Phase 1

Sponsor

Gynecologic Oncology Group

61 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00104910

The ClinicalTrials.gov registry entry for NCT00104910 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 64 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Gynecologic Oncology Group, which has 61 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 9 conditions, with Cervical Squamous Cell Carcinoma appearing as the primary indexed condition, and to 4 interventions — of which Cisplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00104910 reports 15 study locations spanning 10 distinct geographic areas — top geographies include Ohio, Texas, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00104910 about?

NCT00104910 is a clinical study titled "Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer". This phase I trial is studying the side effects and best dose of cetuximab when given together with cisplatin and radiation therapy in treating patients with stage IB, stage II, stage III, or stage IVA cervical cancer. Monoclonal antibodies, such as cetuximab, can block tumor growth in different way...

What is the current status of trial NCT00104910?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 64 participants. The study started on 2005-01.

What conditions does trial NCT00104910 study?

This clinical trial studies the following conditions: Cervical Squamous Cell Carcinoma, Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Small Cell Carcinoma, Stage IVA Cervical Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00104910?

The interventions under investigation include: Cisplatin (DRUG), Cetuximab (BIOLOGICAL), 3-Dimensional Conformal Radiation Therapy (RADIATION), Internal Radiation Therapy (RADIATION). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00104910?

This trial is sponsored by Gynecologic Oncology Group, which has 61 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00104910 being conducted?

This trial has 15 study locations across Georgia, Illinois, Indiana, Iowa, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial