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NCT06542497 · ClinicalTrials.gov registry record · Phase 3
Evaluate Efficacy and Safety of POS to Improve Distance-corrected Near Visual in Participants With Presbyopia
A Phase 3 study, sponsored by Ocuphire Pharma.
- Completed
- Registry status
- Phase 3
- Development phase
- 569
- Enrollment target
NCT06542497: Completed Phase 3 study, sponsored by Ocuphire Pharma.
NCT06542497 is a Phase 3 study that has completed, run by Ocuphire Pharma. The registered enrollment target is 569 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (26% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06542497, a Phase 3 study, has completed, sponsored by Ocuphire Pharma.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 569 participants
- Enrollment target
Study Summary
Safety and efficacy of POS in participants with presbyopia
Primary Outcome
The primary efficacy endpoint is the percentage of participants with ≥ 15 letters of improvement in binocular DCNVA and with \< 5 letters of loss in binocular BCDVA from baseline comparing POS-treated participants to placebo-treated participants at 12 hours post-dose at Visit 4 (Day 8).
Interventions
- DRUG Placebo
- DRUG 0.75% phentolamine ophthalmic solution
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 569 participants |
| Start Date | 2024-08-15 |
| Est. Completion | 2026-01-22 |
| Phase | Phase 3 |
What the finished NCT06542497 record still lists
NCT06542497 is an interventional study that assigns participants to a tested intervention. The registered 569 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (26% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT06542497 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06542497 about?
NCT06542497 is a clinical study titled "Evaluate Efficacy and Safety of POS to Improve Distance-corrected Near Visual in Participants With Presbyopia". Safety and efficacy of POS in participants with presbyopia
What is the current status of trial NCT06542497?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 569 participants. The study started on 2024-08-15. Estimated completion is 2026-01-22.
What interventions are being tested in trial NCT06542497?
The interventions under investigation include: Placebo (DRUG), 0.75% phentolamine ophthalmic solution (DRUG).
Who is sponsoring clinical trial NCT06542497?
This trial is sponsored by Ocuphire Pharma, which has 14 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06542497's enrollment target sits among peer trials
569 666th of 2000 higher than 1,335 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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