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NCT06537401 · ClinicalTrials.gov registry record · NA
Metabolic Adaptations to High-fat Diet
A NA study, sponsored by George Washington University.
- Terminated
- Registry status
- NA
- Development phase
- 2
- Enrollment target
NCT06537401: Clinical Trial NA study, sponsored by George Washington University.
NCT06537401 is a NA study that was terminated before completion, run by George Washington University. The registered enrollment target is 2 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06537401, a NA study, was terminated before completion, sponsored by George Washington University.
- TERMINATED
- Registry status
- NA
- Development phase
- 2 participants
- Enrollment target
Study Summary
The purpose of this study is to understand how the body's response after a meal is influenced by insulin and sugar in the blood. The primary question this study seeks to address is what is the effect of reduced insulin sensitivity on postprandial metabolic flexibility to an oral glucose tolerance test. We will recruit 50 adults (ages 20-45; 50% female) who are otherwise healthy (no known clinical diagnosis) into our non-randomized crossover trial to determine the effect of changes in insulin sensitivity on metabolic response to feeding. Insulin sensitivity will be decreased using a three-day high-fat diet (HFD) with extra calories. Whole-body metabolism will be measured during a standard 75-gram oral glucose tolerance test (OGTT). Metabolic response to feeding (e.g. OGTT) will be compared before and after the HFD and compared with the control diet to understand the effect of decreased insulin sensitivity on the metabolic response to feeding. The role of biological sex as a moderator of the effect of increased insulin resistance on postprandial metabolic flexibility will also be investigated
Primary Outcome
Mean difference respiratory exchange ratio during an oral glucose tolerance test following a high fat diet
Interventions
- BEHAVIORAL Hypercaloric, High Fat Diet
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2 participants |
| Start Date | 2024-08-12 |
| Est. Completion | 2024-12-31 |
| Phase | NA |
Why NCT06537401 stopped before completion
NCT06537401 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 2 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 1 intervention - of which Hypercaloric, High Fat Diet is the first listed.
NCT06537401 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT06537401 about?
NCT06537401 is a clinical study titled "Metabolic Adaptations to High-fat Diet". The purpose of this study is to understand how the body's response after a meal is influenced by insulin and sugar in the blood. The primary question this study seeks to address is what is the effect of reduced insulin sensitivity on postprandial metabolic flexibility to an oral glucose tolerance te...
What is the current status of trial NCT06537401?
This trial is currently terminated. It is a NA study. The enrollment target is 2 participants. The study started on 2024-08-12. Estimated completion is 2024-12-31.
What interventions are being tested in trial NCT06537401?
The interventions under investigation include: Hypercaloric, High Fat Diet (BEHAVIORAL).
Who is sponsoring clinical trial NCT06537401?
This trial is sponsored by George Washington University, which has 133 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT06537401's enrollment target sits among peer trials
2 1997th of 2000 the lowest of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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